Exhaled nitric oxide monitoring by quantum cascade laser: comparison with chemiluminescent and electrochemical sensors

Journal of Biomedical Optics
Julien MandonSimona M Cristescu

Abstract

Fractional exhaled nitric oxide (F(E)NO) is considered an indicator in the diagnostics and management of asthma. In this study we present a laser-based sensor for measuring F(E)NO. It consists of a quantum cascade laser (QCL) combined with a multi-pass cell and wavelength modulation spectroscopy for the detection of NO at the sub-part-per-billion by volume (ppbv, 110(-9)) level. The characteristics and diagnostic performance of the sensor were assessed. A detection limit of 0.5 ppbv was demonstrated with a relatively simple design. The QCL-based sensor was compared with two market sensors, a chemiluminescent analyzer (NOA 280, Sievers) and a portable hand-held electrochemical analyzer (MINO, Aerocrine AB, Sweden). F(E)NO from 20 children diagnosed with asthma and treated with inhaled corticosteroids were measured. Data were found to be clinically acceptable within 1.1 ppbv between the QCL-based sensor and chemiluminescent sensor and within 1.7 ppbv when compared to the electrochemical sensor. The QCL-based sensor was tested on healthy subjects at various expiratory flow rates for both online and offline sampling procedures. The extended NO parameters, i.e. the alveolar region, airway wall, diffusing capacity, and flux were calc...Continue Reading

References

Dec 16, 1991·Biochemical and Biophysical Research Communications·L E GustafssonS Moncada
Jan 1, 1997·American Journal of Respiratory and Critical Care Medicine·P E SilkoffN Zamel
Aug 4, 1998·Journal of Applied Physiology·N M Tsoukias, S C George
Apr 14, 2000·American Journal of Respiratory and Critical Care Medicine·P E SilkoffS Permutt
Dec 2, 2000·Clinical Physiology·H EkroosA R Sovijärvi
Jan 25, 2002·Applied Physics. B, Lasers and Optics·L MenzelW Urban
May 1, 2002·International Archives of Occupational and Environmental Health·P H FischerJ G C van Amsterdam
Mar 26, 2004·Nature Reviews. Microbiology·Anthony P Turner, Naresh Magan
Apr 9, 2005·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society, UNKNOWN European Respiratory Society
Sep 2, 2005·The European Respiratory Journal·I HorváthUNKNOWN ATS/ERS Task Force on Exhaled Breath Condensate
Jul 28, 2006·Pediatric Pulmonology·Claire McGillStephen W Turner
May 2, 2007·Physiological Measurement·M M L SteeghsF J M Harren
Jul 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·Rafal LewickiGerard Wysocki
Apr 27, 2010·Respiratory Research·Anna SelbyGraham Roberts
Mar 8, 2011·Journal of Breath Research·Matthew R McCurdyFrank K Tittel
Dec 1, 2007·Journal of Breath Research·M Högman, P Meriläinen
Mar 10, 2011·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Collin R BrooksJeroen Douwes

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Citations

Sep 3, 2014·Trends in Biotechnology·Nicholas J W RattrayStephen J Fowler
Jan 26, 2013·Allergology International : Official Journal of the Japanese Society of Allergology·Sujoy Khan
Sep 23, 2014·Applied Spectroscopy·Lizhu ZhangBenli Yu
Aug 18, 2017·Chemical Society Reviews·Andreas SchwaighoferBernhard Lendl
Apr 28, 2017·The European Respiratory Journal·Ildiko HorváthTeunis J Vink
Jan 15, 2014·Journal of Breath Research·B de Lacy CostelloN M Ratcliffe
Sep 6, 2017·Journal of Breath Research·M Metsälä
Mar 1, 2013·Journal of Breath Research·S M CristescuM Högman
Jan 6, 2015·Journal of Breath Research·Liying PengHaiyang Li
Aug 2, 2017·Scientific Reports·Laurent M PaardekooperSimona M Cristescu
Dec 9, 2020·Journal of Breath Research·Wei LeiJian-An Huang
Jan 22, 2021·Journal of Breath Research·Thibault ChollierIrène Ventrillard

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