Exhaled nitric oxide, systemic inflammation, and the spirometric response to inhaled fluticasone propionate in severe chronic obstructive pulmonary disease: a prospective study

Therapeutic Advances in Respiratory Disease
Ken M KunisakiDennis E Niewoehner

Abstract

A subset of patients with chronic obstructive pulmonary disease (COPD) may respond more favorably to inhaled corticosteroids (ICS), but no simple method is currently utilized to predict the presence or absence of ICS responses in patients with COPD.We evaluated the ability of exhaled nitric oxide (FENO) and serum inflammatory markers (C-reactive protein [CRP], interleukin-6 [IL-6], and interleukin-8 [IL-8]) to independently predict spirometric responses to ICS in patients with COPD. Among 60 ex-smokers with severe COPD (mean FEV1 1.07 L, 36% of predicted), we conducted a single-arm, open-label study. Participants spent four weeks free of any ICS, followed by four weeks of ICS use (fluticasone propionate 500 mcg twice daily). FENO, CRP, IL-6, IL-8, and pre-bronchodilator spirometry were measured immediately before and after the four weeks of ICS use. Baseline FENO, CRP, IL-6, and IL-8 showed no correlations to FEV1 responses to ICS. ICS responders (increase in FEV1 > or = 200 mL after four weeks of ICS) did have significantly higher baseline FENO levels compared with non-responders (46.5 parts per billion [ppb] vs. 25 ppb, p = 0.028). The receiver operating characteristic curve for FENO to discriminate responders from non-respon...Continue Reading

References

Aug 1, 1995·American Journal of Respiratory and Critical Care Medicine·S A KharitonovP J Barnes
Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine
Feb 1, 1995·Clinical Science·S A KharitonovP J Barnes
May 1, 1996·American Journal of Respiratory and Critical Care Medicine·R A RobbinsR G Townley
May 1, 1997·American Journal of Respiratory and Critical Care Medicine·P ChanezJ Bousquet
Mar 28, 1998·American Journal of Respiratory and Critical Care Medicine·W MaziakP J Barnes
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·E PizzichiniF E Hargreave
Nov 21, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H KanazawaJ Yoshikawa
Jan 5, 1999·American Journal of Respiratory and Critical Care Medicine·J L HankinsonK B Fedan
Jan 3, 2001·The New England Journal of Medicine·UNKNOWN Lung Health Study Research GroupMelissa Skeans
Feb 24, 2001·Respiratory Medicine·A C OlinK Torén
Aug 15, 2001·Chest·P MontuschiP J Barnes
Nov 13, 2001·American Journal of Respiratory and Critical Care Medicine·A A EidD J Shale
Mar 19, 2002·The Journal of Allergy and Clinical Immunology·Stanley J SzeflerUNKNOWN Asthma Clinical Research Network of the National Heart Lung, and Blood Institute
Jul 2, 2002·American Journal of Respiratory and Critical Care Medicine·Graziella TuratoMarina Saetta
Oct 31, 2002·American Journal of Respiratory and Critical Care Medicine·Juanita H VernooyEmiel F Wouters
Jun 25, 2004·The New England Journal of Medicine·James C HoggPeter D Paré
Jul 2, 2004·American Journal of Respiratory and Critical Care Medicine·Don D SinS F Paul Man
Jan 15, 2005·Pulmonary Pharmacology & Therapeutics·Jörg D LeuppiMichael Tamm
Apr 9, 2005·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society, UNKNOWN European Respiratory Society
May 20, 2005·American Journal of Respiratory and Critical Care Medicine·Andrew D SmithD Robin Taylor
Sep 17, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M A BerryI D Pavord
May 18, 2007·American Journal of Respiratory and Critical Care Medicine·Klaus F RabeUNKNOWN Global Initiative for Chronic Obstructive Lung Disease

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Citations

Apr 27, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jack F Dummer, D R Taylor
Feb 27, 2010·American Journal of Respiratory and Critical Care Medicine·Ken M Kunisaki
Sep 11, 2012·Multidisciplinary Respiratory Medicine·Barbara Piras, Marc Miravitlles
Feb 12, 2011·International Journal of Chronic Obstructive Pulmonary Disease·Ken M Kunisaki, Thomas S Rector
May 14, 2009·International Journal of Chronic Obstructive Pulmonary Disease·Umme KolsumDave Singh
Nov 3, 2009·Annals of Thoracic Medicine·Abdullah A Abba
Sep 8, 2015·International Journal of Environmental Research and Public Health·Marlene Cortez-LugoAlbino Barraza-Villarreal
Dec 27, 2011·Archivos de bronconeumología·Marc MiravitllesJuan José Soler-Cataluña
Feb 27, 2016·Nitric Oxide : Biology and Chemistry·B Alcázar-NavarreteO Ruiz-Rodriguez
Feb 26, 2015·Current Allergy and Asthma Reports·Stephen BujarskiNicola A Hanania
Apr 11, 2014·BioMed Research International·Mario MalerbaFabio L M Ricciardolo
Dec 30, 2014·Archivos de bronconeumología·Bernardino Alcázar NavarreteUNKNOWN Working Group “Consensus document on the appropriate use of inhaled corticosteroids in COPD”
Mar 29, 2011·Archivos de bronconeumología·Marc Miravitlles
Mar 30, 2017·Expert Review of Respiratory Medicine·Terence HoParameswaran Nair
Dec 15, 2010·Clinical Physiology and Functional Imaging·Annamari RouhosAnssi R A Sovijärvi
Jan 31, 2012·Expert Review of Respiratory Medicine·Naomi SpitaleAndrew McIvor
Mar 8, 2011·Journal of Breath Research·Matthew R McCurdyFrank K Tittel
Dec 18, 2015·European Clinical Respiratory Journal·Andrei MalinovschiZuzana Diamant
Aug 23, 2020·Journal of Clinical Medicine·Keiji OishiYasuhiro Gon
Jun 18, 2020·International Journal of Chronic Obstructive Pulmonary Disease·Xiaoling ZhangShujuan Jiang

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