Exhaled NO reference limits in a large population-based sample using the Lambda-Mu-Sigma method

Journal of Applied Physiology
Tiago JacintoKjell Alving

Abstract

Absolute values are used in the interpretation of the fraction of exhaled nitric oxide (FeNO), but it has been suggested that equations to calculate reference values may be a practical and clinically useful approach. We hypothesize that the application of the Lambda-Mu-Sigma (LMS) method may improve FeNO reference equations and their interpretation. Our aims were to develop FeNO reference equations with the LMS method and to describe the difference between this method and the absolute fixed cut-offs of the current recommendations. We utilized the United States National Health and Nutrition Examination Surveys 2007-2012 and included healthy individuals with no respiratory diseases and blood eosinophils <300/mm3 ( n = 8,340). Natural log-transformed FeNO was modeled using the LMS method, imbedded in the generalized additive models for location, scale, and shape models. A set of FeNO reference equations was developed. The explanatory variables were sex, age, height, smoking habits, and race/ethnicity. A significant proportion of individuals with normal FeNO given by the equations were classified as having intermediate levels by the current recommendations. Further lower predicted FeNO compared with previous linear models was seen....Continue Reading

References

Jul 1, 1992·Statistics in Medicine·T J Cole, P J Green
Dec 1, 1996·The European Respiratory Journal·J O LundbergK Alving
Jul 4, 2003·Pediatric Research·Christophe PedrolettiKjell Alving
Sep 8, 2004·Statistics in Medicine·Robert A Rigby, D Mikis Stasinopoulos
Mar 2, 2005·The European Respiratory Journal·J E BrusseeJ C de Jongste
Apr 9, 2005·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society, UNKNOWN European Respiratory Society
Oct 8, 2005·The Journal of Allergy and Clinical Immunology·Cherie LambertBrian M Freed
Nov 3, 2005·The European Respiratory Journal·R PellegrinoJ Wanger
Feb 13, 2007·The Journal of Allergy and Clinical Immunology·Céline BergeronQutayba Hamid
Feb 17, 2007·American Journal of Respiratory and Critical Care Medicine·Maria TsoumakidouPeter K Jeffery
Nov 17, 2007·American Journal of Respiratory and Critical Care Medicine·Sanja StanojevicTim J Cole
Nov 27, 2007·The Journal of Allergy and Clinical Immunology·Marc C LevesqueJohn S Sundy
Jan 31, 2008·Respiration; International Review of Thoracic Diseases·Anna MeuronenAnnika Laitinen
Nov 13, 2008·Pediatric Pulmonology·Tom Kovesi, Robert Dales
Sep 19, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Alessandra SandriniDeborah H Yates
Sep 22, 2009·The Journal of Allergy and Clinical Immunology·Andrew D SmithD Robin Taylor
Jul 3, 2010·The European Respiratory Journal·S StanojevicJ Stocks
Jul 22, 2010·The New England Journal of Medicine·Paul D Scanlon, Mark D Shriver
Sep 3, 2011·American Journal of Respiratory and Critical Care Medicine·Raed A DweikUNKNOWN American Thoracic Society Committee on Interpretation of Exhaled Nitric Oxide Levels (FENO) for Clinical Applications
Jan 1, 2011·Clinical and Translational Allergy·Daniela LinharesJoão A Fonseca
Jun 30, 2012·The European Respiratory Journal·Philip H QuanjerUNKNOWN ERS Global Lung Function Initiative
Jul 14, 2012·The Clinical Respiratory Journal·Tiago JacintoJoão Fonseca
Aug 18, 2012·The Clinical Respiratory Journal·Dora LudviksdottirAndrei Malinovschi
Mar 19, 2014·Respiratory Medicine·Leif BjermerOmar Usmani
May 21, 2015·Journal of Breath Research·Tiago JacintoKjell Alving
Jul 18, 2015·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Charlotte Heijkenskjöld-RentzhogKjell Alving
Jan 1, 2013·International Journal of Chronic Diseases·Mann Ying Lim, Paul S Thomas
May 4, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N Al-ShamkhiA Malinovschi
Nov 5, 2016·The European Respiratory Journal·Philip H Quanjer, Sanja Stanojevic

❮ Previous
Next ❯

Citations

Sep 25, 2019·Journal of Epidemiology·Li-Ping XieFang Liu
Jun 15, 2021·Clinical and Translational Allergy·Rita AmaralKjell Alving

❮ Previous
Next ❯

Software Mentioned

GAMLSS
R
SPSS Statistics

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Primary Care Respiratory Journal : Journal of the General Practice Airways Group
Artur Gevorgyan, Wytske J Fokkens
The Journal of Allergy and Clinical Immunology
Joseph D SpahnStanley J Szefler
© 2022 Meta ULC. All rights reserved