PMID: 9551756Apr 29, 1998Paper

Exhaled single-breath nitric oxide measurements are reproducible, repeatable and reflect levels of nitric oxide found in the lower airways

The European Respiratory Journal
E GabbayP A Corris

Abstract

Measurement of exhaled nitric oxide (NO) may allow noninvasive assessment of inflammatory disease in the lung. We determined immediate and day-to-day reproducibility of single-breath NO measurements at different points on the exhaled test, and whether levels recorded reflect levels of NO in the lower airways. Using a rapid chemiluminescence analyser, 55 healthy control subjects performed three sequential tests on each of two days. NO levels were compared at the level corresponding with: 1) the time the mouth pressure fell below 4 cmH2O (MP); 2) the plateau of end-exhaled CO2 (CO2); and 3) the NO plateau (NOp). NO levels were measured directly from the lower airways of 15 lung transplant recipients and compared with NO levels from a single-breath test performed in the same cohort. For measurements performed at MP, CO2 and NOp, the mean +/- SD differences between the two closest levels performed on the same day were 0.11+/-0.18, 0.095+/-0.16 and 0.094+/-0.13 parts per billion (ppb), respectively, and between days were 0.18+/-0.76, 0.19+/-0.78 and 0.17+/-0.8 ppb, respectively. End-expiratory levels recorded at the mouth from a single-breath test and in the lower airways were highly correlated (mouth versus trachea r2=0.95, p<0.000...Continue Reading

Citations

Feb 19, 2010·European Journal of Applied Physiology·Sara K RosenkranzCraig A Harms
Mar 19, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Marc EstenneSamuel Yousem
Dec 2, 2000·Clinical Physiology·H EkroosA R Sovijärvi
Mar 17, 2004·Current Opinion in Pulmonary Medicine·Andrew Chan, Roblee Allen
Dec 10, 1999·American Journal of Respiratory and Critical Care Medicine·E GabbayT J Williams
Oct 24, 2001·American Journal of Respiratory and Critical Care Medicine·A De SoyzaP A Corris
Jun 16, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Michael E BowdishMark L Barr
Mar 6, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P G Gibson
Nov 23, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C NeurohrUNKNOWN Munich Lung Transplant Group
Dec 10, 1999·Pulmonary Pharmacology & Therapeutics·M Bernareggi, G Cremona
Jan 22, 2015·Journal of Exposure Science & Environmental Epidemiology·Jaime Mirowsky, Terry Gordon
Jun 27, 2006·Respiratory Medicine·Harri StarkHannu Tukiainen
Oct 7, 2004·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Gerd DöringUNKNOWN Consensus Study Group
Jul 26, 2016·Frontiers in Physiology·Cyril KaramaounBenoît Haut
Sep 27, 2016·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Pernille Bækgaard UdesenVibeke Backer
Apr 4, 2009·Journal of Applied Physiology·Yannick Kerckx, Alain Van Muylem
Oct 6, 2021·Journal of Breath Research·Jing ZhangYixiang Duan

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