Exhaustion of the Frank-Starling mechanism in conscious dogs with heart failure induced by chronic coronary microembolization

Life Sciences
Robert M GillWeiqun Shen

Abstract

The role of the Frank-Starling mechanism in the regulation of cardiac systolic function in the ischemic failing heart was examined in conscious dogs. Left ventricular (LV) dimension, pressure and systolic function were assessed using surgically implanted instrumentations and non-invasive echocardiogram. Heart failure was induced by daily intra-coronary injections of microspheres for 3-4 weeks via implanted coronary catheters. Chronic coronary embolization resulted in a progressive dilation of the left ventricle (12+/-3%), increase in LV end-diastolic pressure (118+/-19%), depression of LV dP/dt(max) (-19+/-4%), fractional shortening (-36+/-7%), and cardiac work (-60+/-9%), and development of heart failure, while the LV contractile response to dobutamine was depressed. A brief inferior vena caval occlusion in dogs with heart failure decreased LV preload to match the levels attained in their control state and caused a further reduction of LV dP/dt(max), fractional shortening, stroke work and cardiac work. Moreover, in response to acute volume loading, the change in the LV end-diastolic dimension-pressure (DeltaLVEDD-DeltaLVEDP) curve in the failing heart became steeper and shifted significantly to the left, while the increases in...Continue Reading

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Citations

Nov 4, 2006·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Isaac GeorgeJie Wang
Jul 24, 2010·Canadian Journal of Physiology and Pharmacology·Leonardo dos SantosPaulo J F Tucci
Oct 27, 2015·European Heart Journal·Arnold M Katz, Ellis L Rolett
Jun 24, 2011·International Journal of Cardiology·David H MacIver, Mark J Dayer
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May 29, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Shunsuke SaitoYoshiki Sawa
Aug 1, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Robert M GillWeiqun Shen
Sep 14, 2017·British Journal of Clinical Pharmacology·Ahmed Al-NaherMunir Pirmohamed
Feb 27, 2017·Journal of Applied Physiology·Eva RomitoFrancis G Spinale
Apr 11, 2018·The American Journal of Emergency Medicine·Metin ÇağdaşTufan Çınar

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