Exhaustive submaximal endurance and resistance exercises induce temporary immunosuppression via physical and oxidative stress

Journal of Exercise Rehabilitation
Chan-Ho JinJoo-Young Kim

Abstract

Regular running and strength training are the best ways to improve aerobic capacity and develop the size of skeletal muscles. However, uncontrolled physical activities can often lead to an undertraining or over-training syndrome. In particular, overtraining causes persistent fatigue and reduces physical performance due to changes in the various physiological and immunological factors. In this study, we gave an exhaustive submaximal endurance or resistance exercise to participants and investigated the relationship between physical stress (cortisol level in blood), oxidative stress (intracellular ROS accumulation), and adaptive immune response (CD4:CD8 ratio). Ten male volunteers were recruited, and performed a submaximal endurance or resistance exercise with 85% of VO2max or 1-repetition maximum until exhaustion. Blood samples were collected at rest, and at 0 and 30 min after the exercise. Cortisol levels, oxidative stress, and immune cell phenotypes in peripheral blood were evaluated. Cortisol levels in the sera increased after the exhaustive endurance and resistance exercises and such increments were maintained through the recovery. Intra-cellular ROS levels also increased after the exhaustive endurance and resistance exercise...Continue Reading

Citations

Jul 23, 2016·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Jaqueline Santos Moreira LeiteJulio Tirapegui
Dec 1, 2017·Sports Medicine - Open·Paula Andréa Malveira CavalcanteRonaldo Carvalho Araújo
Nov 23, 2016·Frontiers in Physiology·Feng HeLi Zuo
Jan 11, 2020·Frontiers in Physiology·Sheila Estruel-AmadesMargarida Castell
Jul 25, 2019·International Journal of Environmental Research and Public Health·Rodrigo PoderosoJosé Vilaça-Alves
Oct 4, 2020·International Journal of Environmental Research and Public Health·Emanuela FaelliPiero Ruggeri
Oct 3, 2018·Journal of Exercise Rehabilitation·Chan-Ho JinJoo Young Kim
Jun 14, 2021·Free Radical Biology & Medicine·Ionara Rodrigues SiqueiraLaura Reck Cechinel

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Methods Mentioned

BETA
fluorescence-activated cell sorting

Software Mentioned

FlowJo

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