Existence of different alpha(1)-adrenoceptor subtypes in junctional and extrajunctional neurovascular regions in canine splenic arteries

British Journal of Pharmacology
X P Yang, S Chiba

Abstract

The present study attempted to characterize the alpha(1)-adrenoceptor subtypes mediating vasoconstrictor responses to administered and nerve stimulation-evoked noradrenaline (NA) release in the isolated and perfused canine splenic artery. A previous study demonstrated that periarterial electrical nerve stimulation (30 s trains of pulses at a frequency of 1, 4 or 10 Hz) induced a double peaked vasoconstriction consisting of an initial transient, predominantly P2X-purinoceptor-mediated constriction followed by a prolonged, mainly alpha(1)-adrenoceptor-mediated response in the canine splenic artery. The effects of alpha(1)-adrenoceptor subtype antagonists on neuronally-mediated second peaked vasoconstrictions were analysed. BMY 7378 (10 - 100 nM), a selective alpha(1D)-adrenoceptor antagonist produced a dose-dependent inhibition of the second peak responses at all frequencies used. BMY 7378 (100 nM) reduced these responses by approximately 30%. Exposure of tissues to chloroethylclonidine (CEC, 60 microM), a selective alpha(1B)-adrenoceptor antagonist attenuated the second peak response by approximately 60%, even in the presence of BMY 7378 (100 nM). On the other hand, WB 4101 (100 nM), a selective alpha(1A)-adrenoceptor antagonist...Continue Reading

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Citations

Jun 24, 2003·European Journal of Pharmacology·Yongxin Yu, Michael C Koss
Feb 9, 2002·British Journal of Pharmacology·Fumiko SuzukiIkunobu Muramatsu
Jul 18, 2003·Autonomic & Autacoid Pharmacology·M NakazawaS Chiba
Aug 13, 2005·Autonomic Neuroscience : Basic & Clinical·Alex A Pérez-RiveraJames J Galligan
Feb 18, 2017·Autonomic Neuroscience : Basic & Clinical·Hussain Al Dera, James A Brock
Jan 6, 2004·Journal of Glaucoma·Hiroshi KobayashiSatoshi Okinami
Apr 4, 2002·Japanese Journal of Pharmacology·Shigetoshi Chiba, Miyoko Tsukada
Jul 2, 2003·Journal of Pharmacological Sciences·Shigetoshi Chiba, Xiao-Ping Yang
Sep 27, 2003·Autonomic & Autacoid Pharmacology·S Chiba, X-P Yang

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