Existence of functional alpha1A- and alpha1D- but no alpha1B-adrenoceptor subtypes in rat common carotid arteries

Japanese Journal of Pharmacology
Shigetoshi Chiba, Miyoko Tsukada

Abstract

Using the cannula inserting method, vasoconstrictor responses to alpha1-adrenoceptor agonists (noradrenaline [NA], phenylephrine [PE] and methoxamine [ME]) and effects of alpha1-adrenoceptor antagonists (WB4101, chloroethylclonidine [CEC] and BMY7378) were investigated in isolated and perfused rat common carotid arteries. The rank order of agonist potency and efficacy was NA = PE > ME. Either WB4101 or BYM7378 inhibited NA- and PE-induced constrictions in a dose-related manner. CEC did not inhibit the NA- and PE-induced responses. The ME-induced responses were also significantly blocked by either WB4101 or BMY7378. From these results, it is concluded that there are functional alpha1A- and alpha1D-adrenoceptor subtypes in rat common carotid arteries, but no functional alpha1B subtype.

References

Feb 1, 1983·Journal of Pharmacological Methods·K Hongo, S Chiba
Jan 16, 1995·European Journal of Pharmacology·A S GoetzD L Saussy
Apr 1, 1997·Naunyn-Schmiedeberg's Archives of Pharmacology·M YangM C Michel
Apr 27, 2000·European Journal of Pharmacology·M B Hussain, I Marshall

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Citations

Jan 20, 2006·Journal of Veterinary Pharmacology and Therapeutics·H ZerpaJ Elliott

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