Existence of multiple receptors in single neurons: responses of single bullfrog olfactory neurons to many cAMP-dependent and independent odorants

Brain Research
M KashiwayanagiK Kurihara

Abstract

The responses of single bullfrog olfactory neurons to various odorants were measured with the whole-cell patch clamp which offers direct information on cellular events and with the ciliary recording technique to obtain stable quantitative data from many neurons. A large portion of single olfactory neurons (about 64% and 79% in the whole-cell recording and in the ciliary recording, respectively) responded to many odorants with quite diverse molecular structures, including both odorants previously indicated to be cAMP-dependent (increasing) and independent odorants. One odorant elicited a response in many cells; e.g. hedione and citralva elicited the response in 100% and 92% of total neurons examined with the ciliary recording technique. To confirm that a single neuron carries different receptors or transduction pathways, the cross-adaptation technique was applied to single neurons. Application of hedione to a single neuron after desensitization of the current in response to lyral or citralva induced an inward current with a similar magnitude to that applied alone. It was suggested that most single olfactory neurons carry multiple receptors and at least dual transduction pathways.

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Citations

Dec 28, 2018·Clinical and Experimental Otorhinolaryngology·Hisami FujioKen-Ichi Nibu
Jul 10, 1999·The Journal of General Physiology·A Iida, M Kashiwayanagi
Oct 29, 2003·The Journal of General Physiology·Hiroko Takeuchi, Takashi Kurahashi
Aug 27, 2003·The Journal of General Physiology·Hiroko TakeuchiTakashi Kurahashi
Oct 13, 2000·The European Journal of Neuroscience·K Inamura, M Kashiwayanagi
Jul 1, 2011·Indian Journal of Psychological Medicine·Richard J RobertsMary Ann Roberts
Jun 8, 1999·The Journal of Physiology·K InamuraK Kurihara
Jun 2, 2005·The European Journal of Neuroscience·Rebecca ElsaesserJacques Paysan

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