PMID: 6169250Jan 1, 1980Paper

Exit routes for secretory proteins from the dog pancreas

Acta physiologica Academiae Scientiarum Hungaricae
M PappG Folly

Abstract

The relative importance of the pancreatic venous and lymphatic routes for the transport of enzymes away from the pancreas was investigated. The activities of lipase and amylase were compared in arterial plasma, pancreaticoduodenal lymph and venous plasma, pancreatic interstitial fluid and juice in 31 anaesthetized dogs. Enzyme activities were determined before, during and after stimulation of the acinar parenchyma by 4 U/kg b.w. secretin + CCK-PZ for 60 min. During stimulation either is the juice secreted into the duodenum or we ligated the main pancreatic duct. Enzyme output was calculated as the volume x enzyme activity. Initial activities of both enzymes were higher in lymph than in plasma samples. Pancreatic stimulation raised the level of both enzymes in plasma. Stimulation raised lymph lipase activity higher than in plasma, even without duct ligation. Duct ligation increased enzyme activities to considerably higher values in oedema fluid than in lymph. When enzyme output in the stimulated juice for 60 min was considered 100%, output in plasma volume (5% of b.w.) was about 15% both for lipase and for amylase during stimulated secretion, 25--30% for both enzymes when duct had been ligated. Lymphatic enzyme output was found ...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.