Exocrine Pancreas in Cats With Diabetes Mellitus

Veterinary Pathology
E ZiniC E Reusch

Abstract

Pancreatitis has been described in cats with diabetes mellitus, although the number of studies currently available is very limited. In addition, ketoacidosis has been hypothesized to be associated with pancreatitis in diabetic cats. The aims of the present study were to investigate whether diabetic cats have pancreatitis and to determine if pancreatitis is more frequent with ketoacidosis. Samples of pancreas were collected postmortem from 37 diabetic cats, including 15 with ketoacidosis, and 20 control cats matched for age, sex, breed, and body weight. Sections were stained with hematoxylin and eosin, double-labeled for insulin/CD3, insulin/CD20, insulin/myeloperoxidase, insulin/PCNA, and glucagon/Ki67, and single-labeled for Iba1. A previously proposed semiquantitative score was used to characterize pancreatitis, along with counts of inflammatory cells. Scores of pancreatitis and the number of neutrophils, macrophages, and lymphocytes in the exocrine pancreas did not differ between diabetic and control cats or between diabetic cats with and without ketoacidosis. Of note, PCNA-positive acinar cells were increased (P = .002) in diabetic cats, particularly near islets (P < .001). Ki67-positive acinar cells were increased only nea...Continue Reading

References

Mar 21, 1998·Journal of Veterinary Internal Medicine·M M GoossensS M Griffey
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Oct 18, 2005·Molecular and Cellular Biology·Jeroen EssersWim Vermeulen
Mar 28, 2006·Schweizer Archiv für Tierheilkunde·C E ReuschN Sieber-Ruckstuhl
Jan 2, 2007·Veterinary Pathology·H E V De CockS L Marks
Apr 24, 2007·Journal of Feline Medicine and Surgery·Annalisa PrahlLarry T Glickman
Jul 22, 2008·Journal of Feline Medicine and Surgery·Yaiza ForcadaLaura Blackwood
Oct 18, 2008·Diabetes, Obesity & Metabolism·L Baeyens, L Bouwens
May 23, 2012·Veterinary and Comparative Oncology·M J LindermanG S Post
Feb 26, 2014·Veterinary Pathology·E ZiniL Aresu

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Methods Mentioned

BETA
light microscopy
biopsy
biopsies

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