PMID: 3409185Sep 15, 1988Paper

Exocrine pancreatic function following intraoperative irradiation of the canine pancreas

Cancer
F Ahmadu-SukaC E Whiteman

Abstract

Twenty-four beagles received intraoperative irradiation (IORT) with 6 meV electrons to the pancreas and the duodenum. Intraoperative irradiation doses of 17.5 to 40 Gy were given. Billroth II gastrojejunostomy was done to bypass the irradiated duodenum. Six control dogs received only the Billroth II surgery. Two weeks postoperatively, irradiated dogs were given 50 Gy of 6 MV X radiation (external-beam radiation [EBRT]) to the pancreas and duodenum in 2 Gy fractions over a 5-week period. Dogs were monitored clinically and exocrine pancreatic function was evaluated using an N-benzoyl-l-tyrosyl-para-aminobenzoic acid (BT-PABA) test between 3 and 135 days postoperatively. Necropsies were performed on the dogs at 135 days postoperatively. The degree of gross pancreatic atrophy in the irradiated group was dose related. The mean percentage of normal acinar cells correlated with IORT doses and para-aminobenzoic acid (PABA) values (P less than 0.1). Weight loss was significantly greater in the irradiated dogs compared to the control (P less than 0.05) and the mean percentage of body weight loss correlated with the mean PABA values (P less than 0.01). In this study, the use of the BT-PABA test to evaluate progressive exocrine pancreatic ...Continue Reading

References

Jan 1, 1979·Digestion·C J MitchellM S Losowsky
Dec 1, 1968·American Journal of Surgery·V Wachtfeidl, M Vítĕz
Jul 1, 1983·International Journal of Radiation Oncology, Biology, Physics·J E TepperT Padikal
Oct 1, 1983·International Journal of Radiation Oncology, Biology, Physics·B C ZookC C Rogers
Dec 1, 1982·American Journal of Clinical Oncology·J R CastroT L Phillips
Feb 1, 1980·International Journal of Radiation Oncology, Biology, Physics·R KomakiR W Kline
Jul 1, 1981·International Journal of Radiation Oncology, Biology, Physics·M Abe, M Takahashi

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Citations

Mar 1, 1994·Zhonghua wai ke za zhi [Chinese journal of surgery]·Z G JiaD P Pei
Sep 25, 2001·Micron : the International Research and Review Journal for Microscopy·Agnes TelbiszZoltán Somosy
Jul 1, 1993·Annals of Surgery·D B EvansT A Rich
Dec 29, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jerzy WydmanskiBarbara Maslyk
Sep 1, 1994·Current Problems in Cancer·P A JohnstoneT J Kinsella
Feb 5, 2009·The American Journal of Gastroenterology·Luisa GuarnerJ-R Malagelada
Jun 26, 2014·Langenbeck's Archives of Surgery·Matthew T McMillan, Charles M Vollmer
Dec 6, 2019·Frontiers in Oncology·Douglas H Thamm

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