Exocrine Pancreatic Neoplasms of Nonductal Origin: Acinar Cell Carcinoma, Pancreatoblastoma, and Solid-Pseudopapillary Neoplasm

Surgical Pathology Clinics
Nobuyuki Ohike, Toshio Morohoshi

Abstract

This review describes the clinicopathologic characteristics, differential diagnosis, and biologic behavior of exocrine pancreatic tumors of predominantly nonductal differentiation: acinar cell carcinoma, pancreatoblastoma, and solid-pseudopapillary neoplasm. Patients usually present with a well-demarcated, large, soft, solitary mass with expansile, rather than infiltrative, growth pattern. Cystic change is common. Histologically, the tumors usually reveal at least a focal solid, cellular appearance composed of uniform, monomorphic epithelial cells. However, each type has characteristic clinicopathological features. The immunohistochemical labeling profile of pancreatoblastoma parallels the multiple lines of differentiation. These tumors are capable of producing metastases; however, their behavior is different among the types and even in the same type. Therefore, establishment of a grading system that can predict the outcome would be helpful.

References

Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·T MorohoshiT Mitsuya
Aug 1, 1994·The American Journal of Surgical Pathology·D S KlimstraC S Heffess
Jan 21, 2003·The Journal of Pathology·Yukichi TanakaHiroshi Horie
Nov 2, 2004·Virchows Archiv : an International Journal of Pathology·Nobuyuki OhikeGünter Klöppel
Aug 31, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Katharina TiemannGünter Klöppel
Aug 10, 2007·Pathology International·Nobuyuki OhikeToshio Morohoshi
Jun 11, 2010·The American Journal of Surgical Pathology·Daisuke BanNobuyoshi Hiraoka
Sep 28, 2010·The American Journal of Surgical Pathology·Vikram DeshpandeRobert H Young

❮ Previous
Next ❯

Citations

Aug 3, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·P Pérez SeguraE Aranda
Sep 13, 2013·British Journal of Pharmacology·C GüngörM Bockhorn
May 15, 2013·Korean Journal of Pathology·Adam D TollSyed Z Ali
Dec 24, 2019·Archives of Pathology & Laboratory Medicine·Elizabeth D Thompson, Laura D Wood
Nov 13, 2020·Pathologica·Claudio LuchiniAldo Scarpa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
David S Klimstra
Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Davide AntonelloAldo Scarpa
Radiographics : a Review Publication of the Radiological Society of North America, Inc
Ellen M ChungRichard M Conran
Journal of Hepato-biliary-pancreatic Sciences
Terumi KamisawaShin-Ichiro Horiguchi
© 2021 Meta ULC. All rights reserved