PMID: 6165067Jan 1, 1980Paper

Exocrine pancreatic secretion and immunoreactive secretin release after repeated intraduodenal infusions of bile in man

Scandinavian Journal of Gastroenterology
M OsnesM Otte

Abstract

The exocrine pancreatic secretion of water, bicarbonate, amylase, trypsin, chymotrypsin, and lipase and the plasma concentration of immunoreactive secretin (IRS) were studied before and after repeated intraduodenal infusions of cattle bile in man. After endoscopic cannulation of the main pancreatic duct, juice was collected in 5-min samples for 20 min. A solution of 6 g dried cattle bile in 60 ml water was then infused into the duodenum through a separate catheter attached to the outside of the duodenoscope. Juice was collected for another 20 min. After this period a solution of 6 g dried cattle bile in 40 ml water was infused into the duodenum, and juice again collected for 20 min. Blood was frequently drawn from an arm vein for estimation of plasma concentration of secretin by radioimmunoassay. Both bile infusions caused significant rises in flow rate, bicarbonate concentration and output, and IRS (p less than 0.05). Enzyme concentrations decreased significantly after intraduodenal bile infusions (p less than 0.05). Outputs of enzymes rose significantly after the first bile infusion; however, a rise after the second bile infusion was found only for amylase. Further, a significant decrease in amylase and lipase concentration w...Continue Reading

References

Jan 1, 1977·Scandinavian Journal of Gastroenterology·L E Hanssen, P Torjesen
Nov 1, 1973·The American Journal of Digestive Diseases·S J Konturek, P Thor
Jan 1, 1972·Digestion·P LehnertE Werle
Jan 1, 1971·Scandinavian Journal of Gastroenterology·M M ForellH P Stahlheber
Oct 15, 1966·Klinische Wochenschrift·M M Forell, H Stahlheber
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Jun 25, 1965·Deutsche medizinische Wochenschrift·H WEBER
Jun 22, 1926·The Journal of Physiology·J Mellanby

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Citations

Nov 26, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P W ThimisterJ B Jansen
May 1, 1985·Digestive Diseases and Sciences·S BondesenO B Schaffalitzky de Muckadell
Jul 2, 1998·Acta Physiologica Scandinavica·S S SaetreO B Schaffalitzky de Muckadell
May 1, 1993·Scandinavian Journal of Gastroenterology·R L Riepl, P Lehnert
Aug 1, 1992·Scandinavian Journal of Gastroenterology·R L Riepl, P Lehnert
Jan 1, 1987·Scandinavian Journal of Gastroenterology. Supplement·M V Singer
Jan 1, 1987·Scandinavian Journal of Gastroenterology. Supplement·P LehnertR Riepl
Sep 1, 1986·Scandinavian Journal of Gastroenterology·L E HanssenH Goebell
Oct 1, 1990·European Journal of Clinical Investigation·I Koop

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