Nov 12, 1975

Exocytosis couples to endocytosis of ferritin in parotid acinar cells from isoprenalin stimulated rats

Cell and Tissue Research
M Kalina, R Robinovitch

Abstract

Distribution of acid phosphatase as a marker enzyme for lysosomes was investigated in the isoprenalin stimulated rat parotid gland. The enzyme was localized in lipofuscin-like bodies as well as in non-discharged granules. The appearance of these bodies was correlated in time to the appearance of smooth vesicles and reduction of the acinar lumen. Ferritin, used as a tracer and introduced into the stimulated gland via cannulated parotid ducts, was found in smooth vesicles, vacuoles and lipofuscin-like bodies throughout the cytoplasm of the acinar cells. Very often ferritin-containing vesicles were found in the vicinity of the Golgi complex. In most cases the vesicles containing ferritin also showed acid phosphatase reaction product. A possible correlation between the lysosomal system and the process of recycling and degradation of membranes in the stimulated gland is discussed.

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Mentioned in this Paper

Acid Phosphatase
Tissue Membrane
Entire Lumen of Body System
Golgi Apparatus
Endocytosis
Vesicle
Lipofuscin
Lysosomes
Parotid Gland
Novodrin

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