Exogenous activated NK cells enhance trafficking of endogenous NK cells to endometriotic lesions

BMC Immunology
Mary Lourdes MontenegroPer H Basse

Abstract

Endometriosis is defined as the presence of endometrial glands and stroma at ectopic locations. Although the prevalence of endometriosis is as high as 35%-50%, its pathogenesis remains controversial. An increasing number of studies suggest that changes in immune reactivity may be primarily involved in the development of endometriosis development. In this sense, it has been strongly suggested that a fundamental part of immunologic system, the natural killer cells (NK cells), are an important part of this process. NK cells, a component of the innate immune system, have been extensively studied for their ability to defend the organism against infections and malignancy. Recent studies have shown that IL-2-activated NK (A-NK) cells are able to attack and destroy tumors in lungs and livers of mice, demonstrating the therapeutic potential of these cells. Similarly to metastatic tumor cells, endometrial cells are able to adhere, infiltrate and proliferate at ectopic locations. Therefore, in this study, we evaluated the ability of adoptively transferred and endogenous NK cells to infiltrate endometriosis lesions. As NK cells donors were used C57BL/6 B6. PL- Thy 1.1 female mice. As uterine horns donors were used C57/BL6+GFP female mice a...Continue Reading

References

Feb 13, 2001·Fertility and Sterility·D I LebovicR N Taylor
Jun 13, 2002·Molecular Biotechnology·Per H BasseRonald B Herberman
Apr 25, 2003·International Journal of Cancer. Journal International Du Cancer·Qin YangPer H Basse
Sep 26, 2003·American Journal of Reproductive Immunology : AJRI·Murat Berkkanoglu, Aydin Arici
Nov 16, 2004·Lancet·Linda C Giudice, Lee C Kao
Jan 11, 2007·Journal of Reproductive Immunology·Irene VelascoPedro Acién
Mar 6, 2007·Immunologic Research·Q YangP H Basse
Aug 8, 2008·Fertility and Sterility·Christel MeulemanThomas D'Hooghe

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Citations

Jun 7, 2018·Immunological Investigations·Milena KrálíčkováVaclav Vetvicka
Jan 10, 2018·The Journal of Obstetrics and Gynaecology Research·Gentaro IzumiYutaka Osuga
Jul 25, 2021·Vaccine·Jonathan HechtBarbara Wegiel

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Methods Mentioned

BETA
transgenic

Software Mentioned

MetaMorph

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