PMID: 6979530Apr 1, 1982Paper

Exogenous additions of prostaglandins variably alter the blastogenic response of B and T lymphocytes from different mice lymphoid organs

Immunopharmacology
J M RojoA Portolés

Abstract

Prostaglandins A1 and E2 enhance the 3H-thymidine (TdR) uptake in spleen cell cultures stimulated by two B-lymphocyte mitogens (E.coli lipopolysaccharide (LPS) and dextran sulfate (DXS) at concentrations ranging between 10(-8) and 10(-6) M. The same prostaglandin (PG) concentrations inhibited concanavalin A (Con A) activation of mouse spleen cells depleted or not from a glass-adherent prostaglandin-producing population of suppressor cells. After fractionation of spleen cells by nylon wool adherence, PGs diminished 3H-TdR uptake by nylon nonadherent (T-enriched) cells cultured in the presence of Con A and enhanced the activation of nylon adherent (B-enriched) cells by LPS. The proliferative response of thymic lymphocytes to Con A was drastically inhibited (70-95% by PGE2 10(-8)-10(-6) M. In cultures of purified bone marrow lymphocytes, PGE2 induced a dose-dependent inhibition of either LPS- or DXS-induced activation reaching a 30-40% inhibition at a PGE2 concentration of 10(-6) M. In the spleen, treatment of cells with anti-T sera and complement resulted in abrogation of PG-induced enhancement. Nevertheless, no inhibition of B-cell mitogenesis was observed in the presence of 10(-6) PGE2. From these results, it can be concluded t...Continue Reading

References

Nov 3, 1977·The New England Journal of Medicine·J S GoodwinR C Williams
May 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·O J PlesciaK Grinwich
Jan 1, 1976·Scandinavian Journal of Immunology·E GronowiczA Coutinho
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Citations

Sep 29, 2011·Immunology and Cell Biology·Vinatha SreeramkumarNatalia Cuesta
Oct 18, 2016·Phytotherapy Research : PTR·Carla Marrassini, Claudia Anesini
Sep 5, 2019·International Journal of Molecular Sciences·Shanzana KhanJaye P F Chin-Dusting

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