PMID: 2097586Oct 30, 1990Paper

Exogenous aluminum accumulates in the lysosomes of cultured rat cortical neurons

Neuroscience Letters
J H Schuurmans StekhovenA Stols

Abstract

In order to study the intracellular localization of aluminum, 0.01% AlCl3 was added to rat cerebral organotypic cultures following 14 days incubation in a standard medium. The cultures were maintained in the aluminum (Al)-containing medium for 1 or 3 days. Subsequently, electron probe X-ray micro-analysis (EPXMA), was used to localize aluminum in the neurons. The Al was found in the cells as early as after 1 day of AlCl3 exposure. The Al was detected exclusively in the neuronal lysosomes, in 66% (1 day exposure) and 97% (3 days) of the measured lysosomes. This localization was confirmed by laser microprobe mass analysis (LAMMA) measurements. Our results demonstrate an Al localization in the neurons, exposed to exogenous Al, different from that in the brains of patients with Alzheimer's disease.

Citations

Jan 1, 1993·Annals of Neurology·M A LovellW R Markesbery
Dec 1, 1994·Cellular and Molecular Neurobiology·B Platt, D Büsselberg
Aug 1, 1994·Molecular Neurobiology·R F Itzhaki
Dec 22, 2007·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Daniel KrewskiVirginie Rondeau
Jun 1, 1992·Journal of Neurochemistry·J F LeterrierJ Ulrich
Sep 25, 2004·Journal of Magnetic Resonance·Pamela L BryantLeslie G Butler
Feb 13, 2010·Plant Signaling & Behavior·Frantisek Baluska

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