Exogenous and endogenous cholecystokinin protects gastric mucosa against the damage caused by ethanol in rats

European Journal of Pharmacology
S J KonturekD Drozdowicz

Abstract

Cholecystokinin (CCK) shows a potent influence on gastric secretion and motility but its role in gastric mucosal integrity has been little examined. In this study we found that exogenous CCK octapeptide protected gastric mucosa against ethanol-induced gastric injury but was ineffective against aspirin-induced damage. The protective effects of CCK were dose-dependent and almost completely reversed by pretreatment with the specific CCKA receptor antagonist, loxiglumide, while the CCKB receptor antagonist, L-365,260, was not effective. The CCK-induced protection against ethanol injury was accompanied by a significant increase in gastric blood flow. The inhibition of nitric oxide (NO) synthase by NG-nitro-L-arginine methyl ester attenuated the gastroprotection and gastric hyperemia induced by CCK while the concurrent treatment with L-arginine, but not D-arginine restored the protective activity of CCK and the accompanying increase in gastric blood flow. Endogenous CCK released by intraduodenal instillation of oleate prevented the formation of acute gastric lesions induced by both ethanol and aspirin and the protective effects were abolished by pretreatment with loxiglumide. We conclude that CCK exerts protective activity against et...Continue Reading

References

Jan 1, 1992·The Journal of Physiology·S J KonturekM Cieszkowski
Dec 15, 1992·European Journal of Pharmacology·S J KonturekB Slomiany
May 30, 1991·European Journal of Pharmacology·B M PeskarB A Peskar

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Citations

Jul 17, 1999·European Journal of Pharmacology·C BlandizziM Del Tacca
Nov 27, 2015·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Trina M Norden-KrichmarCindy L Ehlers
Oct 19, 2016·Digestive Diseases and Sciences·Marcin MagierowskiTomasz Brzozowski
Dec 22, 1998·The American Journal of Gastroenterology·J W KonturekW Domschke
Nov 22, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sonlee D WestDavid W Mercer
Apr 30, 2017·Medicina·Gintautas Grabauskas, Chung Owyang
Oct 22, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Masato KomoriMasatsugu Hori
Aug 7, 2021·Frontiers in Pharmacology·Wout VerbeurePeter R van Dijk

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