PMID: 8590310Nov 1, 1995Paper

Exogenous and endogenous type I interferons inhibit interferon-gamma-induced nitric oxide production and nitric oxide synthase expression in murine peritoneal macrophages

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
M DeguchiS Muramatsu

Abstract

We investigated the effect of type I IFNs (IFN-alpha and IFN-beta) on IFN-gamma-induced nitric oxide (NO) production by murine peritoneal macrophages. It was found that exogenous and also endogenous type I IFNs suppressed IFN-gamma-induced NO production, cytosolic inducible NO synthase (iNOS) activity, and iNOS mRNA accumulation in macrophages. Furthermore, we show here that type I IFNs prevent the NO-mediated deterioration of mitochondrial respiratory activity in macrophages. These results seem to indicate a possible protective role of type I IFNs against the NO-mediated immunosuppressive and/or cytotoxic effect of macrophages.

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Citations

Jun 1, 2011·The Journal of Experimental Medicine·Erin E ZollerMichael B Jordan
May 2, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S Y YaoS Sriram
Aug 26, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·E López-CollazoL Boscá
Jan 1, 1997·Annual Review of Immunology·U BoehmJ C Howard
May 17, 2005·Nitric Oxide : Biology and Chemistry·Alan P KumarWanda F Reynolds
Mar 1, 2011·Mycobiology·Yehia A-G MahmoudEman H F Abd El-Zaher
Oct 12, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·H E MarshallJ S Stamler
May 31, 1996·The Journal of Biological Chemistry·J A LewisP Najarro
Jun 3, 2020·Journal of Cellular and Molecular Medicine·Nataliia KalynovskaJiri Palecek
Apr 20, 2013·The Journal of Biological Chemistry·Martin Lee, Jonathan C Choy
Jun 5, 1998·The Journal of Biological Chemistry·A K Kiemer, A M Vollmar
Oct 25, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S K MannaB B Aggarwal
Feb 1, 1997·Trends in Neurosciences·G L HallN J Scolding

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