Exogenous carcinoembryonic antigen-related cell adhesion molecule 1 suppresses 2,4,6-trinitrobenzene sulfonic acid-induced ulcerative colitis in mice

The Journal of Surgical Research
Yu JinChangqing Zheng

Abstract

Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is known to play an immunomodulatory role in a variety of tumors, but its role in ulcerative colitis (UC) remains to be elucidated. The present study aimed to investigate the effects of exogenous CEACAM1 on UC using a mouse model. UC in female Balb/c mice was induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS). Hundred microliters of 1% TNBS was supplied through abdominal smearing for sensitization. Then after 7 d, 100 μL 0.5% TNBS was administered by a transrectal injection. After injection, the mice were placed in an upside-down position for 1 min. The CEACAM1 treatment was performed by receiving a transrectal injection of 10(9) pfu of CEACAM1. The mice were weighed, and the colonic mucosa damage was scored. The effects of exogenous CEACAM1 expression on mouse colon inflammation, apoptosis, and CD4 T lymphocyte infiltration in UC were examined. CEACAM1 expression was significantly reduced in the colon tissue of mice with UC, and the expression of exogenous CEACAM1 improved the symptoms of UC, as evidenced by hematoxylin-eosin staining and histopathologic scores. Moreover, exogenous CEACAM1 reduced the levels of inflammatory cytokines, suppressed CD4 T cell ...Continue Reading

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