Exogenous catalase may potentiate oxidant-mediated lung injury in the female Sprague-Dawley rat

Journal of Toxicology and Environmental Health
C LardotR Lauwerys

Abstract

Enhancement of lung antioxidant capacity has been proposed in the therapy of acute lung injuries involving local accumulation of reactive oxygen species (ROS). We have studied in the female Sprague-Dawley rat the effect of intratracheal administration of catalase (CAT) on the acute lung response induced by different ROS generating systems. The lung response was assessed at several time intervals (60-360 min) by monitoring in bronchoalveolar fluid (BALF) the activity of lactate dehydrogenase and the levels of total protein, albumin, and glucose. While CAT (50,000 IU/rat) significantly reduced the biochemical changes induced by hydrogen peroxide produced by a glucose/glucose oxidase system, it markedly exacerbated the lesions induced by phorbol myristate acetate (PMA). Several observations indicate that a particular chemical species formed during the catalase inactivation process is responsible for this effect. Parallel to the development of the lung damage, we noted a rapid reduction of CAT activity (80%) in the BALF of animals treated with PMA and CAT. In vitro an inhibition of CAT activity was observed in the presence of a superoxide anion generating system, and this inhibition was prevented by superoxide dismutase (SOD). A do...Continue Reading

Citations

Aug 27, 1999·Trends in Pharmacological Sciences·M Patel, B J Day
Oct 26, 1999·Brain Research. Molecular Brain Research·S JayanthiJ L Cadet
Oct 11, 2002·Free Radical Biology & Medicine·Kevin R SmithKent E Pinkerton
Oct 24, 2009·Epilepsy Research·Simon Waldbaum, Manisha Patel
Dec 18, 2003·Annals of the New York Academy of Sciences·Kathryn HaskinsJennifer Kench

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