Exogenous glycosaminoglycans modulate extracellular and intracellular accumulation of newly synthesized glycosaminoglycans by embryonic chick skin fibroblasts

Cell Biology International Reports
R EvangelistiP Carinci

Abstract

The effects of exogenous glycosaminoglycans (GAG) on newly synthesized GAG accumulation in intra- and extra-cellular compartments of 17 incubation days chick embryonic skin fibroblasts have been examined. Exogenous GAG are able to act on both total GAG synthesis and secretion by embryonic fibroblasts and on the relative concentration of individual GAG. A decline in hyaluronic acid and an increase in chondroitin sulfate plus dermatan sulfate in the cellular compartment for all GAG administered have been detected. There was also similar behaviour in the extracellular compartment after sulfated GAG administration.

Citations

Mar 1, 1995·Cell Biochemistry and Function·R EvangelistiP Locci
Sep 14, 2000·Journal of Biomedical Materials Research·P LocciE Becchetti
Oct 21, 2003·Journal of Biomedical Materials Research. Part a·Lorella MarinucciPaola Locci

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