Exogenous gonadotropin stimulation is associated with increases in serum androgen levels in in-vitro fertilization-embryo transfer cycles

Fertility and Sterility
K A MartinR L Barbieri

Abstract

To examine serum androgen profiles in women undergoing ovarian stimulation with exogenous gonadotropins in the setting of IVF-ET. Prospective study. University hospital IVF-ET program. Seventeen ovulatory women undergoing IVF-ET for endometriosis, male factor infertility, or tubal disease. A standard long protocol of GnRH agonist (GnRH-a) pretreatment (1 mg of leuprolide acetate SC for 10 days) was administered before ovulation induction with a urinary gonadotropin preparation. After 10 days of GnRH-a treatment and on the day of hCG administration, serum concentrations of LH, T, androstenedione (A), sex hormone-binding globulin (SHBG), and DHEAS; the free androgen index (T/SHBG); and the number of follicles, oocytes, and embryos were assessed. Serum samples after 10 days of GnRH-a treatment showed incomplete LH suppression. While continuing the agonist during ovarian stimulation, LH values were suppressed further. However, serum T and A concentrations and the free androgen index showed a significant increase (samples drawn just before hCG administration). Serum T levels after 10 days of GnRH-a (before the administration of exogenous gonadotropins) were correlated negatively with the subsequent number of embryos. Serum LH suppre...Continue Reading

References

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Citations

Dec 13, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Raoul OrvietoAntonio La Marca
Dec 1, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Raoul OrvietoBenjamin Fisch
Nov 21, 2020·Reproductive Biomedicine Online·Christine I VaitsopoulouBasil C Tarlatzis

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