Exogenous hydrogen sulfide gas does not induce hypothermia in normoxic mice

Scientific Reports
Sebastiaan D HemelrijkMichal Heger

Abstract

Hydrogen sulfide (H2S, 80 ppm) gas in an atmosphere of 17.5% oxygen reportedly induces suspended animation in mice; a state analogous to hibernation that entails hypothermia and hypometabolism. However, exogenous H2S in combination with 17.5% oxygen is able to induce hypoxia, which in itself is a trigger of hypometabolism/hypothermia. Using non-invasive thermographic imaging, we demonstrated that mice exposed to hypoxia (5% oxygen) reduce their body temperature to ambient temperature. In contrast, animals exposed to 80 ppm H2S under normoxic conditions did not exhibit a reduction in body temperature compared to normoxic controls. In conclusion, mice induce hypothermia in response to hypoxia but not H2S gas, which contradicts the reported findings and putative contentions.

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Citations

Feb 7, 2019·Physiology·Claire A Nordeen, Sandra L Martin
Jan 27, 2019·The Journal of Experimental Biology·Matthew T Andrews
Feb 26, 2019·Therapeutic Hypothermia and Temperature Management·Travis C Jackson, Patrick M Kochanek
Dec 15, 2020·Biological Reviews of the Cambridge Philosophical Society·Zhe ShiXin-Min Liu
Jan 5, 2021·Royal Society Open Science·Dimitri A SkandalisGlenn J Tattersall
Feb 1, 2021·Ageing Research Reviews·Alexander S SokolovAlexey A Moskalev
Feb 9, 2021·Frontiers in Physiology·Sylvain GiroudKenneth B Storey
Sep 7, 2021·The Journal of Experimental Biology·Birgitte S Jensen, Angela Fago

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