Exogenous Ketosis Impairs 30-min Time-Trial Performance Independent of Bicarbonate Supplementation.

Medicine and Science in Sports and Exercise
Chiel PofféPeter Hespel

Abstract

We recently demonstrated that coingestion of NaHCO3 to counteract ketoacidosis resulting from oral ketone ester (KE) intake improves mean power output during a 15-min time trial (TT) at the end of a 3-h cycling race by ~5%. This ergogenic effect occurred at a time when blood ketone levels were low, as ketosis was only induced during the initial ~2 h of the race. Therefore, in the current study, we investigated whether performance also increases if blood ketone levels are increased in the absence of ketoacidosis during high-intensity exercise. In a double-blind crossover design, 14 well-trained male cyclists completed a 30-min TT (TT30') followed by an all-out sprint at 175% of lactate threshold (SPRINT). Subjects were randomized to receive (i) 50 g KE, (ii) 180 mg·kg-1 body weight NaHCO3 (BIC), (iii) KE + BIC, or (iv) a control drink (CON). KE ingestion increased blood d-ß-hydroxybutyrate to ~3-4 mM during the TT30' and SPRINT (P < 0.001 vs CON). In KE, blood pH and bicarbonate concomitantly dropped, causing 0.05 units lower pH and 2.6 mM lower bicarbonate in KE compared with CON during the TT30' and SPRINT (P < 0.001 vs CON). BIC coingestion resulted in 0.9 mM higher blood d-ß-hydroxybutyrate (P < 0.001 vs KE) and completely c...Continue Reading

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May 1, 2019·The Journal of Physiology·Chiel PofféPeter Hespel
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Sep 25, 2020·The Journal of Physiology·Chiel Poffé, Peter Hespel

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Citations

Jun 17, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Nicole M StavitzskiJay B Dean
Mar 2, 2021·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Devin G McCarthyMartin J Gibala
Oct 21, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Chiel PofféPeter Hespel

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Software Mentioned

SPRINT
GraphPad Prism
Power

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