Exogenous nitric oxide inhibits Crimean Congo hemorrhagic fever virus

Virus Research
M SimonAli Mirazimi

Abstract

Crimean Congo hemorrhagic fever virus (CCHFV) is a geographically widespread pathogen that causes severe hemorrhagic fever with high mortality. Even though one of the main objectives focuses on the progress of antiviral agents, the research on CCHFV is strongly hampered due to its BSL-4 classification. Nitric oxide (NO), a mediator with broad biological effects, has been shown to possess inhibitory properties against various pathogens. The molecule constitutes a component of the innate immunity and serves to assist in the early immunological events where it contributes to clearance of microorganisms. In this study, we investigated the inhibitory properties of exogenous NO on CCHFV. We found that NO had a significant antiviral activity against CCHFV replication. By using the NO-donor S-nitroso-N-acetylpenicillamine (SNAP) we were able to show up to 99% reduction in virion progeny yield. In contrast, 3-morpholinosydnonimine hydrochloride (SIN-1), a peroxynitrite donor, had no significant antiviral activity against CCHFV. Furthermore the expression of viral proteins; the nucleocapsid protein and the glycoprotein, were clearly reduced with increasing concentrations of SNAP. We have also shown that the amount of total vRNA in SNAP-t...Continue Reading

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Citations

Jun 8, 2014·Ticks and Tick-borne Diseases·Rafidah LaniKeivan Zandi
Jun 3, 2011·Journal of Virology·Anne-Marie Connolly-AndersenAli Mirazimi
Jan 26, 2010·Scandinavian Journal of Infectious Diseases·E Ediz TütüncüIrfan Sencan
Apr 29, 2011·International Journal of Pediatric Otorhinolaryngology·İsmail Önder UysalSuphi Müderris
Jan 21, 2010·Journal of Medical Virology·Zhihao TanYee-Joo Tan
Dec 18, 2008·The Journal of General Virology·Melinda SimonAli Mirazimi
Aug 24, 2007·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Aynur EnginLevent Ozdemir
Sep 30, 2016·Pathogens and Global Health·Esra TanyelHakan Leblebicioglu
Feb 26, 2009·FEMS Immunology and Medical Microbiology·Umesh C Chaturvedi, Rachna Nagar

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