Exogenous nitric oxide inhibits Rho-associated kinase activity in patients with angina pectoris: a randomized controlled trial

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Tatsuya MaruhashiYukihito Higashi

Abstract

The RhoA/Rho-associated kinase (ROCK) pathway has a key physiological role in the pathogenesis of atherosclerosis. Increased ROCK activity is associated with cardiovascular diseases. Endogenous nitric oxide (NO) has an anti-atherosclerotic effect, whereas the exogenous NO-mediated cardiovascular effect still remains controversial. The purpose of this study was to evaluate the effect of exogenous NO on ROCK activity in patients with angina pectoris. This is a prospective, open-label, randomized, controlled study. A total of 30 patients with angina pectoris were randomly assigned to receive 40 mg day(-1) of isosorbide mononitrate (n=15, 12 men and 3 women, mean age of 63±12 years, isosorbide mononitrate group) or conventional treatment (n=15, 13 men and 2 women, mean age of 64±13 years, control group) for 12 weeks. ROCK activity in peripheral leukocytes was measured by western blot analysis. ROCK activities at 4 and 12 weeks after treatment were decreased in the isosorbide mononitrate group (0.82±0.33 at 0 week, 0.62±0.20 at 4 weeks, 0.61±0.19 at 12 weeks, n=15 in each group, P<0.05, respectively) but not altered in the control group. ROCK1 and ROCK2 expression levels were similar in all treatment periods in the two groups. These...Continue Reading

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Citations

Dec 5, 2015·Frontiers in Pharmacology·Svenja HartmannSusanne Lutz
Mar 24, 2017·International Journal of Urology : Official Journal of the Japanese Urological Association·Yukihito Higashi
Apr 24, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Atsushi Tanaka, Koichi Node
Oct 2, 2019·Experimental and Therapeutic Medicine·Irfan V DüzenAbdullah T Demiryürek
Oct 20, 2020·Medicinal Research Reviews·Achini K VidanapathiranaStephen J Nicholls

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