PMID: 16529009Mar 15, 2006Paper

Exogenous re-infection in tuberculosis

Kekkaku : [Tuberculosis]
Toshiaki Tsuchiya

Abstract

Patients infected by tuberculosis (TB) had been thought to never experience exogenous re-infection. However, exogenous re-infection in HIV-positive patients is well known. Thanks to the introduction of histopathological examination, analysis of similarities in drug-resistance patterns and epidemiological surveys of genetic phage typing for TB infection, we have begun to understand that even people with a normal immune system can experience re-infection. Recent advances in the techniques of restriction fragment length polymorphism (RFLP) and spoligotyping allow determination of similarities in tubercle bacilli, revealing a high ratio of exogenous re-infection. In this mini-symposium, Dr. Kazunari Tsuyuguchi reported cases of nosocomial multidrug-resistant tuberculosis (MDRTB) infection, as exogenous re-infection, at 3 tuberculosis hospitals in the Osaka area. Although the virulence of MDRTB as a variant strain has generally been regarded as weaker than that of drug-sensitive strains, he reported even non-Beijing strain MDRTB, which displays strong virulence, could possess possible infectiosity with a 42% ratio of clustering formation and 2 of 8 patients with MDRTB exhibiting exogenous re-infection, as analyzed by RFLP. Dr. Hideo...Continue Reading

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