Exogenous Reinfection as a Cause of Late Recurrent Tuberculosis in the United States

Annals of the American Thoracic Society
Julia D InterranteNeel R Gandhi

Abstract

The etiology of recurrent tuberculosis is typically presumed to be reactivation of residual Mycobacterium tuberculosis infection, but reinfection may account for a greater proportion of recurrent tuberculosis than previously recognized. To use M. tuberculosis genotyping to characterize the etiology of recurrent tuberculosis occurring 12 months or more after treatment completion. The study population for this national population-based cohort was drawn from the estimated 3,039 persons reported to the National Tuberculosis Surveillance System with two episodes of tuberculosis in the United States during 1993-2011, 194 of whom had genotyping results from both the initial and subsequent episode. We analyzed the proportion of recurrent tuberculosis attributable to and risk factors associated with reinfection. Among 136 recurrences meeting inclusion criteria, genotypes between episodes were the same for 116 (85%) recurrences during 1996-2011; the 20 (15%) with differing genotypes were categorized as reinfections. Using exact logistic regression, factors associated with reinfection included Mexican birth with both TB episodes diagnosed in the United States within 12 years of immigration (adjusted odds ratio, 10.7; 95% confidence interv...Continue Reading

Citations

Nov 18, 2017·BMC Infectious Diseases·Virve KorhonenPetri Ruutu
Apr 26, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sabine M HermansRobin Wood
Oct 21, 2016·Expert Opinion on Therapeutic Patents·Eduardo Filipe OliveiraPedro Alexandrino Fernandes
Apr 6, 2021·Frontiers in Cellular and Infection Microbiology·Yan ShaoCheng Chen

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