Exogenous surfactant application in a rat lung ischemia reperfusion injury model: effects on edema formation and alveolar type II cells.

Respiratory Research
Niels DreyerMatthias Ochs

Abstract

Prophylactic exogenous surfactant therapy is a promising way to attenuate the ischemia and reperfusion (I/R) injury associated with lung transplantation and thereby to decrease the clinical occurrence of acute lung injury and acute respiratory distress syndrome. However, there is little information on the mode by which exogenous surfactant attenuates I/R injury of the lung. We hypothesized that exogenous surfactant may act by limiting pulmonary edema formation and by enhancing alveolar type II cell and lamellar body preservation. Therefore, we investigated the effect of exogenous surfactant therapy on the formation of pulmonary edema in different lung compartments and on the ultrastructure of the surfactant producing alveolar epithelial type II cells. Rats were randomly assigned to a control, Celsior (CE) or Celsior + surfactant (CE+S) group (n = 5 each). In both Celsior groups, the lungs were flush-perfused with Celsior and subsequently exposed to 4 h of extracorporeal ischemia at 4 degrees C and 50 min of reperfusion at 37 degrees C. The CE+S group received an intratracheal bolus of a modified natural bovine surfactant at a dosage of 50 mg/kg body weight before flush perfusion. After reperfusion (Celsior groups) or immediatel...Continue Reading

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Citations

Sep 29, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Christian MühlfeldMatthias Ochs
Jul 24, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Akihiro OhsumiHiroshi Date
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Dec 4, 2020·Journal of Applied Physiology·Xuhua YuWeigang Xu
Jul 6, 2021·Transplantation Reviews·Aadil AliLorenzo Del Sorbo

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Methods Mentioned

BETA
light microscopy
transmission electron microscopy

Software Mentioned

Statistica

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