Exogenous visual orienting is associated with specific neurotransmitter genetic markers: a population-based genetic association study.

PloS One
Rebecca A LundwallJames L Dannemiller

Abstract

Currently, there is a sense that the spatial orienting of attention is related to genotypic variations in cholinergic genes but not to variations in dopaminergic genes. However, reexamination of associations with both cholinergic and dopaminergic genes is warranted because previous studies used endogenous rather than exogenous cues and costs and benefits were not analyzed separately. Examining costs (increases in response time following an invalid pre-cue) and benefits (decreases in response time following a valid pre-cue) separately could be important if dopaminergic genes (implicated in disorders such as attention deficit disorder) independently influence the different processes of orienting (e.g., disengage, move, engage). We tested normal subjects (N = 161) between 18 and 61 years. Participants completed a computer task in which pre-cues preceded the presence of a target. Subjects responded (with a key press) to the location of the target (right versus left of fixation). The cues could be valid (i.e., appear where the target would appear) or invalid (appear contralateral to where the target would appear). DNA sequencing assays were performed on buccal cells to genotype known genetic markers and these were examined for assoc...Continue Reading

References

Apr 1, 1992·Journal of Neuroscience Research·Y Ichimura-OhshimaR Kuwano
Jun 1, 1992·Brain : a Journal of Neurology·R ParasuramanC L Grady
Jan 1, 1972·Psychological Review·R D Luce, D M Green
Jul 30, 1982·Science·R T BartusA S Lippa
Feb 1, 1980·The Quarterly Journal of Experimental Psychology·M I Posner
Dec 1, 1995·Canadian Journal of Experimental Psychology = Revue Canadienne De Psychologie Expérimentale·R D WrightJ J McDonald
Jul 25, 1997·American Journal of Medical Genetics·J F CubellsJ Gelernter
Dec 16, 1998·Schizophrenia Research·M OieK Sundet
Oct 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·P M GreenwoodR Parasuraman
Mar 29, 2001·Current Psychiatry Reports·J SwansonJ Fan
Oct 3, 2001·BMC Neuroscience·J FanM I Posner
Feb 22, 2002·American Journal of Medical Genetics·Chun-Hyung KimKwang-Soo Kim
Feb 28, 2002·American Journal of Epidemiology·W James Gauderman
Apr 13, 2002·Neuropsychology·Raja ParasuramanTrey Sunderland
Jul 16, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Robert A Hegele
Oct 9, 2002·BMC Neuroscience·John FossellaMichael I Posner
Oct 16, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Aiveen KirleyMichael Gill
Apr 2, 2003·The American Journal of Psychiatry·Irving I Gottesman, Todd D Gould
Jan 1, 1963·Annual Review of Physiology·E N SOKOLOV
Sep 27, 2003·British Journal of Psychology·Matthew Kean, Anthony Lambert
Jan 14, 2004·Psychological Bulletin·Kent E HutchisonAngela Bryan
Jul 20, 2004·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Reginald Landry, Susan E Bryson
Sep 25, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Naomi LoweZiarih Hawi
May 20, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Giuseppe BlasiDaniel R Weinberger
Jan 26, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Yiting WangTimothy R Rebbeck
Feb 18, 2006·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Helen E Penn
Jul 21, 2006·Brain Research·Jeff D SandersL Charles Murrin
Jul 28, 2006·Cognitive, Affective & Behavioral Neuroscience·Thomas EspesethRaja Parasuraman
Jan 20, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dao-Qi ZhangDouglas G McMahon
Jun 6, 2007·Neuroscience Letters·John M StarrLawrence J Whalley
Jun 6, 2007·Molecular Psychiatry·M A BellgroveI H Robertson
Jun 21, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Keeley J BrookesUrsula M D'Souza
Oct 25, 2007·European Journal of Human Genetics : EJHG·Jaroslav A HubacekRudolf Poledne
Feb 28, 2008·Experimental Brain Research·Federica RastelliPaolo Bartolomeo
Aug 30, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Nanda N J RommelseJaap Oosterlaan
Jan 15, 2009·Nature Reviews. Neuroscience·Adam E GreenJeremy R Gray
Jan 19, 2010·Psychonomic Bulletin & Review·Shai Gabay, Avishai Henik
Mar 10, 2010·Developmental Psychology·Florian WaszakBernhard Hommel

❮ Previous
Next ❯

Citations

Nov 29, 2015·Developmental Science·Rebecca A LundwallH Hill Goldsmith
Aug 21, 2013·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Daniel CampbellUNKNOWN Learning Disabilities Project: Zambia
Oct 17, 2015·BMC Neuroscience·Rebecca A Lundwall, James L Dannemiller
Jun 24, 2015·PloS One·Rebecca A Lundwall, Jeffrey K Watkins
Aug 22, 2018·Frontiers in Psychology·Rebecca A LundwallSteven P Tolboe
Apr 12, 2020·Scientific Reports·Katarzyna KucAnita Cybulska-Klosowicz
May 25, 2021·Frontiers in Neuroscience·Denise Elfriede Liesa Lockhofen, Christoph Mulert

❮ Previous
Next ❯

Methods Mentioned

BETA
Genotyping
PCR

Software Mentioned

Mutation Surveyor
ANOAVA
Genemapper

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.