Exome Sequencing of Native Populations From the Amazon Reveals Patterns on the Peopling of South America

Frontiers in Genetics
André M Ribeiro-Dos-SantosSandro J de Souza

Abstract

Studies on the peopling of South America have been limited by the paucity of sequence data from Native Americans, especially from the east part of the Amazon region. Here, we investigate the whole exome variation from 58 Native American individuals (eight different populations) from the Amazon region and draw insights into the peopling of South America. By using the sequence data generated here together with data from the public domain, we confirmed a strong genetic distinction between Andean and Amazonian populations. By testing distinct demographic models, our analysis supports a scenario of South America occupation that involves migrations along the Pacific and Atlantic coasts. Occupation of the southeast part of South America would involve migrations from the north, rather than from the west of the continent.

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Citations

Aug 7, 2021·NPJ Biofilms and Microbiomes·Ana Paula SchaanÂndrea Ribeiro-Dos-Santos

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Datasets Mentioned

BETA
PRJEB12437
PRJEB35045

Methods Mentioned

BETA
PCA
exome sequencing
electrophoresis

Software Mentioned

Sambamba
Samtools
BWA MEM
plink
SnpEff
Admixtools
ClinVar
HaplotypeCaller
vcfanno
qpGraph

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