Exophytic condyloma: are they as benign as we think?

Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland
S B JochumD M Hayden

Abstract

As the understanding of anal dysplasia continues to develop, controversy remains regarding treatment of these lesions. The purpose of this study was to evaluate lesion type (flat vs exophytic) and the association between morphology and dysplasia. This was a single-centre retrospective analysis of a prospectively collected pathological database of patients > 17 years old who underwent operative excision/biopsies for presumed anal condyloma or dysplasia from 2009 to 2018. The analysis includes comparisons between patient factors, phenotype and grade of dysplasia. Sixty-nine patients had 423 lesions. The mean age of the study population was 48.2 years. 62.3% were men and 46.4% of patients were black. 47.8% of patients were human immunodeficiency virus (HIV) positive and 39.1% were men who have sex with men (MSM). There were 176 (41.6%) flat lesions and 234 (55.3%) exophytic lesions. Exophytic lesions were 2.5-fold more likely to be associated with a higher grade of dysplasia than flat lesions (OR 2.63, 95% CI 1.09-6.32). Neither lesion type nor dysplasia severity was associated with human papillomavirus, lesion location or patient characteristics, including race, MSM or HIV status. Exophytic lesions were more than twice as likely ...Continue Reading

References

Nov 15, 1989·Journal of the National Cancer Institute·E A HollyJ J Kristiansen
Apr 3, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·J M PalefskyT M Darragh
Aug 19, 2006·ANZ Journal of Surgery·Angus J M WatsonFrank A Frizelle
Aug 30, 2008·Advances in Anatomic Pathology·Teri A LongacreMark L Welton
Feb 27, 2010·The British Journal of Dermatology·A KreuterUNKNOWN German Competence Network HIV/AIDS
Feb 2, 2011·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J H ScholefieldA Radcliffe
Mar 2, 2012·Clinics in Colon and Rectal Surgery·Ignacio Echenique, Benjamin R Phillips
Jun 19, 2012·Diseases of the Colon and Rectum·Scott R SteeleUNKNOWN Standards Practice Task Force of the American Society of Colon and Rectal Surgeons
Mar 20, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rebecca A NelsonLily L Lai
Feb 11, 2014·Diseases of the Colon and Rectum·Stephen E GoldstoneErin L Moshier
Apr 16, 2015·JAMA Surgery·Caitlin W HicksSandy H Fang
Aug 1, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Meredith S ShielsSusan S Devesa
Nov 26, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ina U ParkEileen F Dunne
Mar 2, 2016·Clinics in Colon and Rectal Surgery·Kevin C LongRichard Billingham
Mar 4, 2017·World Journal of Gastrointestinal Oncology·Joseph R RobertsAndrew M Kaz
Apr 12, 2017·Advances in Anatomic Pathology·Eric J YangTeri A Longacre
Jun 8, 2018·Diseases of the Colon and Rectum·David B StewartUNKNOWN Prepared on Behalf of the Clinical Practice Guidelines Committee of the American Society of Colon and Rectal Surgeons
Jul 31, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Stephen E GoldstoneTimothy Wilkin
Nov 7, 2018·Clinics in Colon and Rectal Surgery·Jeffrey Douaiher, Sean J Langenfeld

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Family Physician
Elizabeth V SeiverlingCatherine G Chung
Journal of Clinical and Diagnostic Research : JCDR
Arvind Babu Rajendra SantoshKumaraswamy Kikeri Laxminarayana
© 2022 Meta ULC. All rights reserved