Exopolysaccharides as Antimicrobial Agents: Mechanism and Spectrum of Activity.

Frontiers in Microbiology
Abdelmoneim K AbdallaRichard Holley

Abstract

Exopolysaccharides (EPSs) are metabolites synthesized and excreted by a variety of microorganisms, including lactic acid bacteria (LAB). EPS serve several biological functions such as interactions between bacteria and their environments, protection against hostile conditions including dehydration, the alleviation of the action of toxic compounds (bile salts, hydrolyzing enzymes, lysozyme, gastric, and pancreatic enzymes, metal ions, antibiotics), and stresses (changing pH, osmolarity), and evasion of the immune response and phage attack. Bacterial EPSs are considered valuable by the food, pharmaceutical, and nutraceutical industries, owing to their health-promoting benefits and rheological impacts. Numerous studies have reported the unusual antimicrobial activities of various EPS against a wide variety of pathogenic microbes (bacteria, virus, and fungi). This review aims to provide a comprehensive examination of the in vitro and in vivo antimicrobial activities of different EPSs, mainly against foodborne bacterial, fungal, and viral pathogens. The mechanism of EPS action against these pathogens as well as the methods used to measure antimicrobial activities are critically reviewed.

References

Jul 29, 2008·Journal of Pharmaceutical Sciences·Sameer SharmaYan Chen
Jul 28, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Barbara VuElena P Ivanova
Jul 28, 2009·Antonie van Leeuwenhoek·Micaela MedranoPablo F Pérez
Feb 17, 2010·Nature Reviews. Microbiology·Sarah LebeerSigrid C J De Keersmaecker
Dec 31, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Arindam ChakrabartiRobert H Silverman
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Saranna FanningDouwe van Sinderen
Mar 9, 2013·Microbiology and Molecular Biology Reviews : MMBR·Breah LaSarre, Michael J Federle
Feb 7, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kulandaipalayam N C SindhuGagandeep Kang
Jun 2, 2014·Probiotics and Antimicrobial Proteins·I Al KassaaD Drider
Dec 24, 2014·International Journal of Biological Macromolecules·Ji WangZhennai Yang
Oct 21, 2015·Frontiers in Microbiology·Misu Moscovici
Dec 19, 2015·Research in Veterinary Science·W M Quinteiro-FilhoS Sharif
Dec 1, 2012·Probiotics and Antimicrobial Proteins·Claudio Hidalgo-CantabranaPatricia Ruas-Madiedo
Mar 30, 2016·Applied Microbiology and Biotechnology·Graziano CaggianielloGiuseppe Spano
Apr 19, 2016·Applied Microbiology and Biotechnology·Victor Haruo MatsubaraLakshman P Samaranayake
Jun 13, 2017·FEMS Microbiology Letters·Eve Maunders, Martin Welch
Aug 5, 2017·Microbial Biotechnology·Camille N AllonsiusSarah Lebeer
Nov 15, 2017·International Journal of Biological Macromolecules·Rizwana Parveen RaniAbraham David Ravindran
Nov 17, 2017·Nature·Marvin WhiteleyE Peter Greenberg
Apr 1, 2016·Journal of Pharmaceutical Analysis·Mounyr BalouiriSaad Koraichi Ibnsouda
Mar 28, 2018·Annual Review of Food Science and Technology·Kieran M LynchElke K Arendt

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacteriophage: Phage Therapy

Phage therapy uses bacterial viruses (bacteriophages) to treat bacterial infections and is widely being recognized as an alternative to antibiotics. Here is the latest research.