EXOSC4 functions as a potential oncogene in development and progression of colorectal cancer

Molecular Carcinogenesis
Yi PanKa Fai To

Abstract

Colorectal cancer (CRC) is a heterogeneous disease with complex mechanisms of pathogenesis. Classification systems have been proposed based on molecular features of tumors in clinical practice. Thus, more molecular markers associated with development and progression of CRC might serve as useful tools for early diagnosis even for providing more accurate molecular classification. Frequent gain of chromosome 8q was detected in CRC by array-CGH and overexpression of exosome component 4 (EXOSC4) in this region was revealed by expression microarray analysis. Through qRT-PCR and immunohistochemistry (IHC) analysis, EXOSC4 showed increased expression in CRC cell lines and clinical specimens. Higher expression of EXOSC4 was more often detected in left side, and correlated with BRAF wild type, MSI-low or MSS, CIMP-low, and MLH1-no-silence CRC patients. Functionally, EXOSC4 overexpression increased early tumorigenic capacity by promoting cell proliferation and monolayer colony formation, enhancing cell invasion and migration study and accelerating xenograft formation in nude mice. While EXOSC4 knockdown exhibited anti-oncogenic role such as inhibiting cell proliferation and invasion. EXOSC4 inhibition also resulted in G1 phase cell cycle ...Continue Reading

References

Jun 1, 1996·In Vitro Cellular & Developmental Biology. Animal·M P MoyerL R Tanzer
Mar 24, 2007·Bioinformatics·Triinu Koressaar, Maido Remm
Nov 28, 2007·Molecular and Cellular Biology·You LiMegerditch Kiledjian
Jan 4, 2008·Molecular Cancer Research : MCR·Jacob Sabates-BellverGiancarlo Marra
Dec 10, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert N JorissenOliver M Sieber
Apr 28, 2010·Gastroenterology·Maria S Pino, Daniel C Chung
Nov 3, 2010·Clinics in Colon and Rectal Surgery·Fatima A Haggar, Robin P Boushey
Jan 29, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shunsuke TsukamotoKenichi Sugihara
Jun 23, 2011·Cancer Informatics·Gwangsik ShinSeon-Young Kim
Sep 14, 2011·The Journal of Clinical Investigation·Daniel T StarczynowskiAly Karsan
Jun 26, 2012·Nucleic Acids Research·Andreas UntergasserSteven G Rozen
Sep 27, 2012·International Journal of Cancer. Journal International Du Cancer·Timo GaiserThomas Ried
Mar 23, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Christoph Kahlert, Raghu Kalluri
May 28, 2013·Cancer Metastasis Reviews·Asfar S AzmiFazlul H Sarkar
Apr 26, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Barbara StefanskaMoshe Szyf
Jun 26, 2014·BioMed Research International·Catarina Roma-RodriguesPedro Viana Baptista
Oct 30, 2014·Nucleic Acids Research·Damian SzklarczykChristian von Mering
Sep 18, 2015·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·Marian GradeJordi Camps
Jun 22, 2016·Virchows Archiv : an International Journal of Pathology·Mike F MüllerMark J Arends
Dec 8, 2016·Nucleic Acids Research·Damian SzklarczykChristian von Mering
Mar 2, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

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