Exosomal cargoes in OSCC: current findings and potential functions

PeerJ
Chengzhi ZhaoWen Liao

Abstract

Oral squamous cell carcinoma (OSCC) is the most prevalent malignancy in head and neck cancer, with high recurrence and mortality. Early diagnosis and efficient therapeutic strategies are vital for the treatment of OSCC patients. Exosomes can be isolated from a broad range of different cell types, implicating them as important factors in the regulation of human physiological and pathological processes. Due to their abundant cargo including proteins, lipids, and nucleic acids, exosomes have played a valuable diagnostic and therapeutic role across multiple diseases, including cancer. In this review, we summarize recent findings concerning the content within and participation of exosomes relating to OSCC and their roles in tumorigenesis, proliferation, migration, invasion, metastasis, and chemoresistance. We conclude this review by looking ahead to their potential utility in providing new methods for treating OSCC to inspire further research in this field.

References

Aug 1, 2006·Journal of Biochemistry·Guillaume van NielGraça Raposo
Mar 1, 2008·Science·Katarina TrajkovicMikael Simons
Mar 26, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Shengming DaiGuisheng Li
Aug 22, 2009·Nature Reviews. Molecular Cell Biology·Barth D Grant, Julie G Donaldson
Jun 24, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Dongmei SunHuang-Ge Zhang
Nov 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·David G MeckesNancy Raab-Traub
May 12, 2011·Cellular and Molecular Life Sciences : CMLS·Bence GyörgyEdit I Buzás
Sep 1, 2011·The EMBO Journal·Jatta Huotari, Ari Helenius
Sep 29, 2011·Traffic·Thomas FalguièresJean Gruenberg
Oct 25, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Shivani SharmaJames K Gimzewski
May 15, 2013·BMC Genomics·Xiaoyi HuangLiang Wang
Sep 21, 2013·Biochimica Et Biophysica Acta·Alicia LlorenteKirsten Sandvig
Oct 22, 2013·Biochimica Et Biophysica Acta·Michel RecordSandrine Silvente-Poirot
Nov 14, 2013·Journal of Extracellular Vesicles·Rossella CrescitelliJan Lötvall
Jan 7, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Cong LuoZhonggui He
Apr 30, 2014·Nature Reviews. Genetics·Kevin V Morris, John S Mattick
Mar 1, 2015·Genomics, Proteomics & Bioinformatics·Jian ZhangShuangli Mi
May 17, 2015·Trends in Molecular Medicine·Kateryna Shostak, Alain Chariot
Jun 28, 2015·Journal of Cancer Research and Clinical Oncology·Ayelet Zlotogorski-HurvitzMarilena Vered
Jul 2, 2015·Stem Cell Research & Therapy·Serena Rubina BaglioD Michiel Pegtel
Jul 29, 2015·CA: a Cancer Journal for Clinicians·Angela C ChiBrad W Neville
Aug 5, 2015·The Journal of Clinical Investigation·Michele W L TengMark J Smyth
Aug 5, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Elena V Batrakova, Myung Soo Kim
Nov 3, 2015·Nature·Ayuko HoshinoDavid Lyden
Dec 19, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F A San LucasH Alvarez
Oct 31, 2016·Advanced Drug Delivery Reviews·Pieter VaderRaymond M Schiffelers
Mar 5, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Scott W Ferguson, Juliane Nguyen
Mar 10, 2016·Recent Patents on Anti-cancer Drug Discovery·Renato J Oliveira-SilvaRui M Reis

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Citations

Aug 28, 2021·Biomedicines·Yousra HamdanGabriel Malka

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