Exosomal MALAT1 derived from oxidized low-density lipoprotein-treated endothelial cells promotes M2 macrophage polarization.

Molecular Medicine Reports
Chaoyang HuangJianhua Zhu

Abstract

Oxidized low-density lipoprotein (oxLDL)-induced injury and apoptosis of endothelial cells are important initial events in numerous cardiovascular diseases. Following activation by oxLDL, monocytes adhere to endothelial cells, migrate into the subendothelial spaces and then undergo differentiation into macrophages, which subsequently induces the formation of atherosclerotic lesions. However, the mechanisms underlying the activation of macrophage differentiation by oxLDL-treated endothelial cells remain unclear. In the present study, it was demonstrated that exosomal metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) was increased in oxLDL-treated human umbilical vein endothelial cells. When co-cultured with monocytes, exosomes extracted from oxLDL-treated HUVECs were endocytosed. Furthermore, exosomes derived from oxLDL-treated endothelial cells were revealed to promote M2 macrophage polarization, as reverse transcription-quantitative polymerase chain reaction, western blotting and ELISA analyses demonstrated increases in the expression of M2 macrophage markers, including macrophage mannose receptor 1 (also termed CD206), arginase-1 and interleukin (IL)-10, and decreases in the expression of the M1 macrophage marke...Continue Reading

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Citations

Mar 7, 2019·Frontiers in Cardiovascular Medicine·Adam W TurnerClint L Miller
Aug 11, 2020·Current Atherosclerosis Reports·Hongyun WangJunjie Xiao
Dec 29, 2020·Frontiers in Pharmacology·Jia LiuJunnan Wang
May 14, 2021·Frontiers in Immunology·Lucas Albacete-AlbaceteMiguel Angel Del Pozo
Jul 27, 2021·Frontiers in Cardiovascular Medicine·Zhu Yuan, Weiqiang Huang
Aug 10, 2021·Frontiers in Physiology·Qing TanJun Li

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