Exosomal microRNA-194 causes cardiac injury and mitochondrial dysfunction in obese mice

Biochemical and Biophysical Research Communications
Hezhongrong NieYiwen Zhou

Abstract

Obesity is associated with increased cardiovascular morbidity and mortality, but the effects of circulating factors on cardiac function is not fully elucidated. Present study aims to explore the pathophysiological role of microRNA (miR)-194, one of hepatic enriched miRs, in the process of obesity-related cardiomyopathy in human subjects and mice. The expression level of circulating exosomal miR-194 was measured in 39 lean and 35 obese human subjects, and correlated with cardiac parameters. The effects of miR-194 on mitochondrial activity and cardiac function were investigated by administration of miR-194 sponge in mouse cardiomyocytes and obesity-related cardiomyopathy. The upregulation of circulating miR-194 level was closely correlated with impaired human cardiac function, including ejection fraction (r = -0.5002, p < 0.01) and NT-proBNP levels (r = 0.3670, p < 0.01). Exosomes from obese mice impaired myocyte mitochondrial activity, but blocking with miR-194 sponge attenuated the exosomal miR-194-induced reduction of ATP production (p < 0.05), basal oxygen consumption (p < 0.01) and mitochondrial complex I activity (p < 0.001). In vivo mouse study, high fat diet damaged cardiac function, normal structure and mitochondrial act...Continue Reading

Citations

Sep 1, 2019·Current Pharmaceutical Design·Caroline D VelosoPaulo J Oliveira
Jun 17, 2020·Clinical Science·Shaojun LiShufeng Li
Oct 16, 2019·Nature Reviews. Endocrinology·Chenbo Ji, Xirong Guo
Sep 24, 2020·International Journal of Molecular Sciences·Adam WłodarskiAgnieszka Śliwińska
Feb 4, 2021·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·Birte WeberLiudmila Leppik
Feb 2, 2021·Journal of Extracellular Vesicles·Jing LiChen-Yu Zhang
Oct 3, 2020·Animal Nutrition·Md Mahmodul Hasan Sohel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiotoxicity

Cardiotoxicity refers to the muscle damage or dysfunction of heart electrophysiology caused by drug intake or due to disease complications. It is a well-known side effect of several cytotoxic drugs, especially of the anthracyclines and can lead to long term morbidity. Here is the latest research.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.