Exosomal miR-1246 in body fluids is a potential biomarker for gastrointestinal cancer

Biomarkers in Medicine
Chunmeng WeiMin He

Abstract

The aim was to systematically evaluate whether exosomal miRNAs could be regarded as potential minimally invasive biomarkers of diagnosis for gastrointestinal cancer. A systematic review and meta analysis of exosomal miRNA expression in gastrointestinal cancer were performed. A total of 370 articles were retrieved from PubMed and EMBASE. The summary receiver operating characteristic curves of three miRNAs (miR-21, miR-1246 and miR-4644) were drawn, miR-21, miR-1246 and miR-4644 exhibited sensitivities of 0.66, 0.920 and 0.750, respectively; specificities were 0.87, 0.958 and 0.769, respectively; and areas under the curve for discriminating gastrointestinal cancer patients from control subjects were 0.876, 0.969 and 0.827, respectively. Exosome miR-1246 had the highest level of diagnostic efficiency, which indicated that miR-1246 could be a biomarker.

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Citations

Sep 12, 2019·International Journal of Clinical Oncology·Yuntao ShiZheng Liu
May 24, 2019·World Journal of Clinical Cases·Lin-Lin SuXiao-Ying Xue
Nov 19, 2019·Journal of Oncology·Valentin VautrotJessica Gobbo
Jan 1, 2020·Cancers·Mohammad Hasan SoheilifarZhixiang Wang
Feb 15, 2020·Scientific Reports·Isamu HoshinoHisahiro Matsubara

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