Exosomal miR-423-5p targets SUFU to promote cancer growth and metastasis and serves as a novel marker for gastric cancer

Molecular Carcinogenesis
Huan YangWen-Rong Xu

Abstract

Exosomes are critically involved in tumor growth, metastasis, and therapy resistance. Exosomes have the potential to be utilized as cancer biomarkers. In this study, we aimed to explore the roles and clinical values of exosomal miRNAs in gastric cancer. We found that the concentration of exosomes was significantly higher in the serum of gastric cancer patients and the culture supernatants of gastric cancer cells than that in healthy volunteers and gastric mucosa epithelial cells. In particular, miR-423-5p was elevated in the serum exosomes of gastric cancer patients, and the level of exosomal miR-423-5p was remarkably correlated with lymph node metastasis. High level of exosomal miR-423-5p was associated with poor outcome in gastric cancer patients. MiR-423-5p enriched exosomes could be internalized into gastric cancer cells, which enhanced cell proliferation and migration both in vitro and in vivo. Mechanistically, miR-423-5p inhibited the expression of suppressor of fused protein (SUFU) to enhance the proliferation and migration of gastric cancer cells. The expression levels of SUFU were significantly decreased in gastric cancer cells and the tumor tissues of gastric cancer patients. Taken together, our findings indicate that...Continue Reading

References

May 3, 2006·Cancer Research·Xin YuArnold J Levine
Apr 25, 2007·Oncogene·Y LeeP J McKinnon
Dec 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·Daniel Y LeeBurton B Yang
Oct 6, 2009·The Journal of Biological Chemistry·Isabella ParoliniStefano Fais
Dec 8, 2009·Nature Cell Biology·Matias OstrowskiClotilde Thery
Jan 1, 2010·Cancer Immunology, Immunotherapy : CII·Jaroslaw BaranMarek Zembala
Nov 30, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Rui LiuChen-Yu Zhang
Mar 15, 2011·Cancer Cell·Mark A EckertJing Yang
Mar 16, 2012·Genes, Chromosomes & Cancer·J SilvaF Bonilla
Jun 5, 2012·Experimental Cell Research·Swayamsiddha KarSamir Kumar Patra
Jun 23, 2012·Pharmacological Reviews·Edwin van der PolRienk Nieuwland
Feb 23, 2013·The Journal of Biological Chemistry·Camilla A ThompsonRalph D Sanderson
May 28, 2013·Cancer Metastasis Reviews·Asfar S AzmiFazlul H Sarkar
Jan 30, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qinyu GeZuhong Lu
Jun 7, 2014·Cancer Medicine·Sirjana ShresthaHsien-Da Huang
Jul 11, 2014·Breast Cancer Research and Treatment·Yifang WeiJian Zhang
Nov 14, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qier LiJunming Guo
Jun 28, 2015·Journal of Cancer Research and Clinical Oncology·Ayelet Zlotogorski-HurvitzMarilena Vered
Jul 15, 2015·Journal of Hematology & Oncology·Xu ZhangWenrong Xu
Jul 15, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Antonella CaivanoLuigi Del Vecchio
Nov 19, 2015·Molecular Cancer·David A ArmstrongCarmen J Marsit
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Lijun WuWenrong Xu
Jun 11, 2016·Oncotarget·Marc Ruiz-MartinezMariano Monzo
Oct 8, 2017·Biochemical and Biophysical Research Communications·Ning WangXin Liu

❮ Previous
Next ❯

Citations

Oct 27, 2018·Journal of Cellular Biochemistry·Keqiu JiangLiming Wang
Nov 23, 2019·Cells·Valentina Karin-KujundzicLjiljana Serman
Apr 21, 2020·Journal of Clinical Laboratory Analysis·Dongming GuoJuntian Chen
Oct 9, 2019·Expert Review of Molecular Diagnostics·Margaritis AvgerisAndreas Scorilas
Apr 9, 2020·Reproductive Biology and Endocrinology : RB&E·Shi XieYanping Li
Mar 17, 2019·Molecular Cancer·Min FuXu Zhang
Apr 23, 2020·Frontiers in Oncology·Qiao-Ru GuoJian-Ye Zhang
Sep 13, 2020·Cancers·Mariantonia LogozziStefano Fais
Feb 2, 2019·World Journal of Clinical Cases·Chi-Hin Wong, Yang-Chao Chen
Feb 9, 2019·Cellular and Molecular Life Sciences : CMLS·Houman KahrobaNasser Samadi
Mar 1, 2020·Molecular Diagnosis & Therapy·Marc HirschfeldThalia Erbes
Jun 6, 2020·Frontiers in Immunology·Alireza Labani-MotlaghAngelica Loskog
Aug 9, 2019·International Journal of Endocrinology·Sida ZhaoYazhuo Zhang
May 10, 2020·Cells·Cristina P R XavierM Helena Vasconcelos
Oct 24, 2020·Nanomedicine·Juliete Nathali SchollFabrício Figueiró
Jan 14, 2021·Seminars in Cancer Biology·Alexander CocksMuller Fabbri
Mar 24, 2021·The International Journal of Biological Markers·Yigang JiaoJingzhe Li
Jun 5, 2021·Advanced Drug Delivery Reviews·Ana ŠpilakChrista Noehammer
Jun 11, 2021·Frontiers in Oncology·Jing GaoLian Liu
Jun 15, 2021·Cancer Treatment and Research Communications·Eijaz Ahmed BhatFahd M Thokar
Jul 27, 2021·Expert Review of Molecular Diagnostics·Raheleh HeydariAnna Meyfour

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.