Exosomal noncoding RNAs in cholangiocarcinoma: Laboratory noise or hope?

World Journal of Gastrointestinal Surgery
Konstantinos LaschosMaria Gazouli

Abstract

Currently, extracellular vesicles and particularly exosomes have gained a lot of research interest due to their unique roles in several biological processes. Noncoding RNAs (microRNAs, long noncoding RNAs and circular RNAs) represent a class of functional RNA with distinct regulatory roles in tumorigenesis and cancer progression. Cholangiocarcinoma is a rare but highly aggressive type of malignancy that is very challenging to diagnose, especially in early stages; surgical resection still represents the sole potentially curative treatment option. Hence, there is an urgent need for the discovery of novel diagnostic and prognostic biomarkers. Hereby, we provide a comprehensive review of the most recent discoveries that focus on exosomal noncoding RNAs in cholangio-carcinoma with the aim to identify new molecular players that could be used as biomarkers and therapeutic targets.

References

Oct 1, 1983·Journal of Pharmaceutical Sciences·L E Gerlowski, R K Jain
Oct 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J ParkT Patel
Jun 13, 2006·Genes & Development·Shane T GrivnaHaifan Lin
Jan 21, 2009·Cell Research·Jian XuRik Derynck
Jul 17, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Anatoliy I MasyukNicholas F LaRusso
Apr 14, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gia L Tyson, Hashem B El-Serag
Aug 3, 2011·Nature Reviews. Gastroenterology & Hepatology·Boris BlechaczGregory J Gores
Aug 10, 2012·World Journal of Gastroenterology : WJG·Yong-Jun ChenSheng-Quan Zou
Jan 3, 2013·European Journal of Cell Biology·Ai-Ying QinShui Cao
Feb 20, 2013·Cancer Letters·Mark KatakowskiMichael Chopp
Feb 20, 2013·The Journal of Cell Biology·Graça Raposo, Willem Stoorvogel
May 15, 2013·BMC Genomics·Xiaoyi HuangLiang Wang
Jun 21, 2013·The Journal of Clinical Endocrinology and Metabolism·Michal SwierniakKrystian Jazdzewski
Jul 11, 2013·International Journal of Molecular Sciences·Bethany N Hannafon, Wei-Qun Ding
Feb 6, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ling LiFlorin M Selaru
May 7, 2014·Cell Biology International·Ugur GezerNejat Dalay
Nov 1, 2012·Intractable & Rare Diseases Research·Xiaobin FengJiahong Dong
Nov 14, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qier LiJunming Guo
Feb 11, 2015·Nature Structural & Molecular Biology·Zhaoyong LiGe Shan
Feb 24, 2015·Mass Spectrometry Reviews·Gabriella PocsfalviKároly Vékey
Mar 15, 2015·Cell·Simon J ConnGregory J Goodall
May 13, 2015·Best Practice & Research. Clinical Gastroenterology·Annika Bergquist, Erik von Seth
May 17, 2015·Journal of Extracellular Vesicles·María Yáñez-MóOlivier De Wever
Jul 1, 2015·Genetics and Molecular Research : GMR·Y J ChenY Q Qi
Sep 24, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Heikki SaariMarjo Yliperttula
Nov 26, 2015·Cancer Biomarkers : Section a of Disease Markers·Meilin QinWenxin Qin
Jan 21, 2016·Scientific Reports·Tiezheng YuanLiang Wang
Feb 26, 2016·Nature Reviews. Molecular Cell Biology·Ling-Ling Chen
Mar 10, 2016·The Journal of Biological Chemistry·Zifeng WangHaifan Lin
Mar 15, 2016·The Journal of Clinical Investigation·Nobuyoshi KosakaTakahiro Ochiya
Apr 2, 2016·The Journal of Clinical Investigation·Jonathan M PittLaurence Zitvogel
Apr 8, 2016·Cellular and Molecular Neurobiology·Erik R Abels, Xandra O Breakefield
Apr 28, 2016·Advances in Clinical Chemistry·Theresa L Whiteside

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection
biopsy
genetic modification

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.