Exosome: a significant nano-scale drug delivery carrier.

Journal of Materials Chemistry. B, Materials for Biology and Medicine
Huan PengXin Zhang

Abstract

In recent years, due to the limitations of the nature of therapeutic agents, many synthetic nano-delivery systems have emerged to enhance the efficacy of drugs. Extracellular vesicles are currently a class of natural nano-scale drug carriers released by cells. As a tiny vesicle with a lipid bilayer membrane that can be secreted by most cells in the body, exosomes carry and transmit important signal molecules, Therefore, they have been a research hotspot in biomedicine and biomaterials due to their size advantages and huge potential in drug therapy. Many people are optimistic about the clinical application prospects of exosomes and are actively exploring the broad functions of exosomes and developing exosome therapeutic agents to make positive contributions to human health. In this review, we provide basic knowledge and focus on summarizing the advantages of exosomes as drug carriers, methods of loading drugs, targeting strategies, in vivo and in vitro tracing methods, and some of the latest developments in exosomes as drug carriers. In particular, the review provides an outlook for this field.

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Citations

Sep 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Batla Al-SowayanAlaa Alshareeda
Oct 13, 2020·Journal of Cellular Physiology·Shenglong Li, Xiaohong Wang
Dec 22, 2020·Frontiers in Pharmacology·Linshen Xie, Ye Zeng
May 29, 2021·International Journal of Nanomedicine·Sasmita SamalMamoni Dash
Jul 15, 2021·Tissue Engineering and Regenerative Medicine·Hojun ChoiChulhee Choi
Jul 27, 2021·Frontiers in Cardiovascular Medicine·Zhu Yuan, Weiqiang Huang

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Methods Mentioned

BETA
biopsy
xenograft
nuclear translocation
transfection
transfect
fluorescence microscopy
transgenic

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