Exosome-delivered microRNAs of "chromosome 19 microRNA cluster" as immunomodulators in pregnancy and tumorigenesis.

Molecular Cytogenetics
Jörn Bullerdiek, Inga Flor

Abstract

Structural rearrangements of chromosomal band 19q13 are a non-random cytogenetic abnormality in thyroid adenomas and adenomatous goiters and lead to an expression of miRNAs of the chromosome 19 microRNA cluster C19MC. Normally, expression of these miRNAs is silenced except for embryonic stem cells and the placenta where they represent the majority of miRNAs not only in the trophoblast but also in exosomes derived from it. We have advanced the hypothesis that as part of the feto-maternal communication miRNAs of C19MC serve immunomodulatory functions in the placenta and confer a growth advantage to thyroid nodules by protecting them against autoimmune attacks. More precisely, the exosomes containing these miRNAs may specifically target immune cells in their local environment as well as systemically by transferring their cargo to recipient cells. Within these target cells the transferred miRNAs can interact with mRNAs of the recipient cells thereby suppressing their immune-specific functions. Experiments used to demonstrate the immunomodulatory capacity of placenta-derived exosomes can be modified by transfecting the target cells with those miRNAs of C19MC represented in placental exosomes. Mimics of C19MC-derived miRNAs might dev...Continue Reading

References

May 1, 1989·Cancer Genetics and Cytogenetics·S BartnitzkeJ Bullerdiek
Jul 1, 1989·Cancer Genetics and Cytogenetics·F SpelemanH Van den Berghe
Jul 28, 2001·Cytogenetics and Cell Genetics·G BelgeJ Bullerdiek
Jun 21, 2005·Nature Genetics·Isaac BentwichZvi Bentwich
Nov 2, 2006·American Journal of Reproductive Immunology : AJRI·Anuradha SabapathaDouglas D Taylor
Apr 18, 2008·Molecular Biology and Evolution·Rui ZhangBing Su
Jul 31, 2008·PloS One·Hong CaoTariq M Rana
Mar 25, 2009·Journal of Translational Medicine·Jiaqiang RenDavid F Stroncek
Mar 25, 2010·American Journal of Reproductive Immunology : AJRI·Lucia Mincheva-Nilsson, Vladimir Baranov
Jul 9, 2010·Human Molecular Genetics·Marie Noguer-DanceJérôme Cavaillé
Mar 11, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·J C WarningJ M Morris
Jun 29, 2011·Transplant Immunology·Marie-Louise P van der HoornFrans H J Claas
Dec 14, 2011·Autoimmunity Reviews·Monika ØstensenFrauke Förger
Mar 1, 2012·The Journal of Pathology·Inga Flor, Jörn Bullerdiek
Mar 3, 2012·Molecular Human Reproduction·R B DonkerYoel Sadovsky
Mar 21, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Claudia AugelloSilvano Bosari

❮ Previous
Next ❯

Citations

May 28, 2013·Cancer Metastasis Reviews·Asfar S AzmiFazlul H Sarkar
Jun 24, 2014·Cellular & Molecular Immunology·Dionne TannettaJennifer Southcombe
Sep 23, 2014·Current Hypertension Reports·Anjali AcharyaTanvi Rege
Jan 15, 2016·British Journal of Cancer·Milan RadovichPatrick J Loehrer
Jul 24, 2015·Expert Review of Molecular Diagnostics·Heidi Schwarzenbach
Jan 8, 2015·Biology of the Cell·Lola Fernández-MessinaHortensia de la Fuente
Nov 27, 2014·Frontiers in Cellular Neuroscience·Hongqi XinMichael Chopp
Oct 16, 2013·Scientific Reports·Timothy K K KamanuVladimir B Bajic
May 10, 2017·Translational Psychiatry·C WrightD R Weinberger
Feb 28, 2017·International Journal of Cancer. Journal International Du Cancer·Duc-Hiep BachSang Kook Lee
Jan 1, 2016·Reproduction, Fertility, and Development·Dawit TesfayeKarl Schellander
Jul 1, 2017·Molecular Reproduction and Development·Mallikarjun Bidarimath, Chandrakant Tayade
Jan 10, 2017·Journal of Cellular Physiology·Hamed MirzaeiMahmoud Reza Jaafari
Mar 16, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Guojing ChangYoel Sadovsky
Mar 20, 2019·MicroRNA·Zacharias FasoulakisEmmanuel N. Kontomanolis
Dec 3, 2017·Archives of Gynecology and Obstetrics·Margarita L Martinez-FierroYolanda Ortiz-Castro
Sep 10, 2020·Frontiers in Immunology·Yupeng HuangQibing Xie
Jul 18, 2017·Journal of Pregnancy·Meng CaiAsif Ahmed
May 26, 2018·Biological Reviews of the Cambridge Philosophical Society·Shama P KabekkoduKapaettu Satyamoorthy
Apr 10, 2019·Annals of Medicine·Tian ZhuLi Li
Feb 5, 2019·Frontiers in Genetics·E Cécile MalnouJérôme Cavaillé
Jun 16, 2019·International Journal of Molecular Sciences·Barbora KonečnáGabriela Repiská
Jun 5, 2021·Experimental Eye Research·Zhihan ZhangMin Fu
Jun 1, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Verónica Zaga-ClavellinaDaniel Ortuño-Sahagún

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.