Exosome-mediated peritoneal dissemination in gastric cancer and its clinical applications

Biomedical Reports
Kai-Bo ChenLi Chen

Abstract

The prognosis of patients with peritoneal dissemination from gastric cancer is poor, and the underlying molecular mechanism remains unclear. Exosomes, as macromolecular phospholipid bilayer vesicles comprising of proteins, nucleic acids and lipids, serve as mediators of cell-cell communication. Gastric cancer tumor-derived exosomes may be involved in the pathological process of peritoneal dissemination by mediating crosstalk between cancer cells and mesothelial cells, to result in the induction of enhanced tumor growth, migratory, adhesive and invasive abilities, peritoneal fibrosis and apoptosis, mesothelial-to-mesenchymal transition, angiogenesis and chemoresistance. The present review focuses on previous studies addressing the exosome-dependent molecular transfer in peritoneal dissemination in gastric cancer and the potential clinical applications.

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Feb 9, 2019·Cellular and Molecular Life Sciences : CMLS·Houman KahrobaNasser Samadi
Jun 11, 2021·Frontiers in Oncology·Jing GaoLian Liu
Jul 27, 2021·Expert Review of Molecular Diagnostics·Raheleh HeydariAnna Meyfour

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