Exosomes and extracellular vesicles: the path forward

Essays in Biochemistry
Philip D Stahl, Graça Raposo

Abstract

Over the course of the past several decades, the concept that extracellular vesicles, exosomes and microvesicles, operate as cellular "housekeepers" and as agents for communication between and among cells and tissues, has emerged into one of the most promising yet vexing problems facing the biomedical community. Already, extracellular vesicles from biological fluids are being used for diagnostic purposes and hopes abound for their use as therapeutic agents. However, the most basic mechanistic questions surrounding their biogenesis and function in cellular and tissue homeostasis remain largely unexplored. In this issue of Essays in Biochemistry, the rise of a new intercellular communications pathway is considered from many perspectives-cell biology, physiology, and pathophysiology.

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Citations

Nov 27, 2018·FEMS Microbiology Reviews·Sukhvinder GillPatrick Forterre
Mar 5, 2019·Plant Signaling & Behavior·Saul Jimenez-JimenezLuis Cárdenas
Aug 6, 2019·Stem Cells·Fanny M ElahiJohnathon D Anderson
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Oct 23, 2019·Frontiers in Molecular Neuroscience·Wanying LiuJunping Zhang
Aug 17, 2019·Traffic·Michel Vidal
Sep 29, 2020·Frontiers in Endocrinology·Yanyan ZhaoGuijun Qin
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Jun 25, 2020·Microbial Biotechnology·Ana MencherRamon Gonzalez
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Jul 25, 2021·International Journal of Molecular Sciences·Francesca ComitiniMaurizio Ciani
Jul 17, 2021·Human Molecular Genetics·Melanie GartzMichael W Lawlor

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