Exosomes from plasmacytoma cells as a tumor vaccine

Journal of Immunotherapy
Stephen L AltieriThomas B Tomasi

Abstract

Exosomes are membrane-bound vesicles derived from multivesicular bodies that are externalized by cells through fusion with the plasma membrane. Exosomes have been implicated in cell-to-cell signaling, and those derived from immunologic cells may be involved in both direct and cross-presentation of antigens to T cells. The research presented here evaluated their efficacy as a prophylactic cancer vaccine in a mouse plasmacytoma model. Plasmacytoma cells were shown to release exosomes in vitro, and vaccination with a single dose (5 microg) of exosome protein protected 80% of mice against challenge with wild-type tumors. Protection could be linked to the immune system since vaccinated mice generated specific cytotoxic T lymphocytes, the effects were not seen in SCID mice, and immunity was tumor-specific. Several proteins involved in immunity, including two potential tumor antigens (P1A and intracisternal A particle protein) as well as Hsp70, were demonstrated to be present in exosomes. The authors conclude that exosomes can induce tumor-specific immunity and prevent tumor development and are a potential strategy for future therapeutic tumor vaccination.

References

Jan 1, 1994·Biology of the Cell·A Amar-CostesecH Beaufay
Dec 1, 1993·Molecular and Cellular Biology·K K LuedersE L Kuff
Mar 1, 1996·The Journal of Experimental Medicine·G RaposoH J Geuze
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·P ZhengY Liu
May 14, 1999·International Immunology·K DrbalV Horejsí
Jul 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K DenzerH J Geuze
Dec 20, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·W J MagnerT B Tomasi
Mar 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicolas BlanchardClaire Hivroz
May 22, 2002·The Journal of Experimental Medicine·Giovanna AndreolaStefano Fais
Aug 3, 2002·Nature Reviews. Immunology·Clotilde ThérySebastian Amigorena
May 14, 2003·Proceedings of the National Academy of Sciences of the United States of America·Inkyu HwangJonathan Sprent
Jun 18, 2003·The Journal of General Virology·James FlanaganTom Sculley
Sep 16, 2003·Journal of Immunotherapy·Di-Hwei HsuJean-Bernard Le Pecq

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Citations

May 9, 2006·Cancer Immunology, Immunotherapy : CII·Thomas B TomasiA Nazmul H Khan
Jan 24, 2008·Immunologic Research·A Nazmul H Khan, Thomas B Tomasi
Nov 6, 2007·Cancer Biotherapy & Radiopharmaceuticals·Siguo HaoJim Xiang
Jul 11, 2012·Advanced Drug Delivery Reviews·Dongmei SunHuang-Ge Zhang
Dec 26, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Michael W GranerDarell D Bigner
Jun 16, 2009·Current Oncology·A Clayton, M D Mason
Jun 7, 2006·Leukemia & Lymphoma·Ning BuBing-Zhong Sun
Jun 15, 2005·Expert Opinion on Biological Therapy·Nathalie ChaputLaurence Zitvogel
Dec 24, 2015·Vaccines·Katherine E Kunigelis, Michael W Graner
Jan 5, 2011·European Urology·Diederick DuijveszGuido Jenster
Aug 5, 2008·Journal of Immunological Methods·Réjean CantinCaroline Gilbert
Sep 10, 2008·Proteomics·Richard J SimpsonJustin W E Lim
Jun 27, 2006·Journal of Cellular and Molecular Medicine·Xiao-Bo LiShun-Qing Xu
Nov 2, 2012·Nephrology·Doreen Yp FangJonathan M Gleadle
May 28, 2013·Biochemical and Biophysical Research Communications·Ye YaoSiguo Hao
Sep 26, 2015·Oncoimmunology·Yanfang LiuXuetao Cao
Dec 25, 2012·Blood Reviews·Yuana YuanaRienk Nieuwland
Apr 9, 2015·Frontiers in Immunology·Steven K LundyDavid A Fox
Sep 19, 2014·PLoS Neglected Tropical Diseases·André Cronemberger-AndradeLain Pontes-de-Carvalho
Mar 15, 2018·Journal of Extracellular Vesicles·Yoosoo YangIn-San Kim
Nov 30, 2006·Arthritis and Rheumatism·K SkrinerG R Burmester
Jul 9, 2005·Expert Review of Anticancer Therapy·Alain DelcayreJean-Bernard Le Pecq
Aug 1, 2006·Journal of Biochemistry·Guillaume van NielGraça Raposo
Jun 23, 2012·Pharmacological Reviews·Edwin van der PolRienk Nieuwland
Apr 7, 2020·Nanomedicine·Juliete Nathali SchollFabrício Figueiró
Aug 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Seon Hee KimPaul D Robbins
Sep 14, 2018·Seminars in Immunopathology·Michael W Graner
Oct 24, 2020·Nanomedicine·Juliete Nathali SchollFabrício Figueiró
Jul 28, 2005·Journal of Cell Science·Aled ClaytonZsuzsanna Tabi
Apr 27, 2021·Bioactive Materials·Komal AbhangeYuan Wan
Aug 3, 2021·Frontiers in Immunology·Patrick Santos, Fausto Almeida
Nov 14, 2020·Molecular Cancer·Zhijie XuYuanliang Yan
Oct 3, 2021·Cell Death & Disease·Qi WuShengrong Sun

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