Exosomes: From Potential Culprits to New Therapeutic Promise in the Setting of Cardiac Fibrosis.

Cells
Roman TikhomirovCostanza Emanueli

Abstract

Fibrosis is a significant global health problem associated with many inflammatory and degenerative diseases affecting multiple organs, individually or simultaneously. Fibrosis develops when extracellular matrix (ECM) remodeling becomes excessive or uncontrolled and is associated with nearly all forms of heart disease. Cardiac fibroblasts and myofibroblasts are the main effectors of ECM deposition and scar formation. The heart is a complex multicellular organ, where the various resident cell types communicate between themselves and with cells of the blood and immune systems. Exosomes, which are small extracellular vesicles, (EVs), contribute to cell-to-cell communication and their pathophysiological relevance and therapeutic potential is emerging. Here, we will critically review the role of endogenous exosomes as possible fibrosis mediators and discuss the possibility of using stem cell-derived and/or engineered exosomes as anti-fibrotic agents.

References

May 4, 1999·The International Journal of Biochemistry & Cell Biology·K T WeberY Sun
Aug 10, 2000·Environmental Health Perspectives·J A Lasky, A R Brody
Mar 7, 2003·Nature·Sean D Conner, Sandra L Schmid
Jul 26, 2003·Blood·Aude de GassartMichel Vidal
Aug 7, 2004·Matrix Biology : Journal of the International Society for Matrix Biology·Annemarie J van der SlotRuud A Bank
Nov 19, 2004·Neoplasia : an International Journal for Oncology Research·Lu XieHarold L Moses
Sep 6, 2005·Science·P CarninciUNKNOWN RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Mar 1, 2008·Science·Katarina TrajkovicMikael Simons
Sep 9, 2008·Biochemical Pharmacology·Preetha AnandBharat B Aggarwal
Dec 31, 2008·Cell Research·Ying E Zhang
Jun 6, 2009·Traffic·Susanne StuffersAndreas Brech
Dec 8, 2009·Nature Cell Biology·Matias OstrowskiClotilde Thery
Jun 24, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Dongmei SunHuang-Ge Zhang
Jul 27, 2010·Critical Reviews in Biochemistry and Molecular Biology·James H Hurley
Jan 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Tamar Harel-AdarSmadar Cohen
Jan 21, 2011·Physiological Reviews·Alex H Hutagalung, Peter J Novick
Mar 23, 2011·Nature Biotechnology·Lydia Alvarez-ErvitiMatthew J A Wood
May 17, 2011·Current Opinion in Cell Biology·Markus Babst
Sep 22, 2011·Expert Review of Cardiovascular Therapy·Bernd Stratmann, Diethelm Tschoepe
Oct 25, 2011·American Journal of Respiratory Cell and Molecular Biology·Satish K MadalaWilliam D Hardie
Apr 13, 2012·Journal of Cellular Physiology·Lior ZilberbergDaniel B Rifkin
May 18, 2012·Molecular Biology of the Cell·Ting-Ting LiuChristopher G Burd
Aug 21, 2012·The International Journal of Biochemistry & Cell Biology·Claudia Bang, Thomas Thum
Aug 22, 2012·Small GTPases·Marc A AntonyakRichard A Cerione
Feb 27, 2013·The Journal of Biological Chemistry·Nobuyoshi KosakaTakahiro Ochiya
Mar 19, 2013·Cell·Pedro J Batista, Howard Y Chang
Apr 2, 2013·Experimental Cell Research·Caroline BaerMichele De Palma
Dec 21, 2013·Nature Communications·Carolina Villarroya-BeltriFrancisco Sánchez-Madrid
Apr 20, 2014·The Journal of Clinical Investigation·Claudia BangThomas Thum
May 16, 2014·Journal of Molecular and Cellular Cardiology·Xiaohong WangGuo-Chang Fan
Jun 18, 2014·Stem Cell Reports·Ahmed Gamal-Eldin IbrahimEduardo Marbán

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Citations

Jun 13, 2020·Frontiers in Physiology·Russell G RogersAhmed G Ibrahim
Oct 6, 2020·Biomedical Optics Express·Vidyani SuryadevaraMichael J Walsh
May 24, 2020·Journal of Neonatal-perinatal Medicine·J J Volpe
Jan 8, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qing LiuWeitie Wang
Jan 24, 2021·Cardiovascular Research·Luke B RobertsGraham M Lord
Dec 5, 2020·Pharmaceutics·Natalia L KlyachkoElena V Batrakova
Mar 7, 2021·Nanomaterials·Laura SaludasMaría J Blanco-Prieto
May 14, 2021·Advanced Drug Delivery Reviews·Fabiana PassaroGianluca Testa
Jun 3, 2021·International Journal of Molecular Sciences·Mihir Parikh, Grant N Pierce
Aug 1, 2021·Advanced Drug Delivery Reviews·Izabela Tuleta, Nikolaos G Frangogiannis
Aug 28, 2021·Frontiers in Cardiovascular Medicine·Selvaraj JayaramanKanagaraj Palaniyandi

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Methods Mentioned

BETA
antisense oligonucleotides
transfection

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