Exosomes Function in Tumor Immune Microenvironment

Advances in Experimental Medicine and Biology
Yin HuangYing Wang

Abstract

Immune cells and mesenchymal stem/stromal cells are the major cellular components in tumor microenvironment that actively migrate to tumor sites by sensing "signals" released from tumor cells. Together with other stromal cells, they form the soil for malignant cell progression. In the crosstalk between tumor cells and its surrounded microenvironment, exosomes exert multiple functions in shaping tumor immune responses. In tumor cells, their exosomes can lead to pro-tumor immune responses, whereas in immune cells, their derived exosomes can operate on tumor cells and regulate their ability to growth, metastasis, even reaction to chemotherapy. Employing exosomes as vehicles for the delivery products to initiate anti-tumor immune responses has striking therapeutic effects on tumor progression. Thus, exosomes are potential therapeutic targets in tumor-related clinical conditions. Here we discuss the role of exosomes in regulating tumor immune microenvironment and future indications for the clinical application of exosomes.

Citations

Aug 8, 2020·Signal Transduction and Targeted Therapy·Jie DaiYiqun Jiang
Jun 5, 2019·Journal of Cellular Physiology·Ali Aghebati-MalekiLeili Aghebati-Maleki
Aug 14, 2020·Journal of Experimental & Clinical Cancer Research : CR·Chongru ZhaoYiping Wu
Jun 21, 2019·International Journal of Molecular Sciences·Loredana AlboniciRoberto Bei
Dec 1, 2020·Critical Reviews in Oncology/hematology·Zijian HuYueqing Gu
Nov 13, 2020·Frontiers in Cell and Developmental Biology·Kaijian ZhouGuoxin Liang
Feb 14, 2021·Biomaterials·Fangmin ChenHaijun Yu
Mar 2, 2021·Biochemical Pharmacology·Ya-Nan PiGe Lou
Nov 14, 2020·Molecular Cancer·Zhijie XuYuanliang Yan
Aug 22, 2021·Immunology Letters·Muzaffer YildirimIhsan Gursel

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