Exosomes in Pathogen Infections: A Bridge to Deliver Molecules and Link Functions

Frontiers in Immunology
Wenchao ZhangLijun Tang

Abstract

Exosomes are extracellular vesicles derived from cell endocytosis which act as transmitters between cells. They are composed of proteins, lipids, and RNAs through which they participate in cellular crosstalk. Consequently, they play an important role in health and disease. Our view is that exosomes exert a bidirectional regulatory effect on pathogen infections by delivering their content. First, exosomes containing proteins and RNAs derived from pathogens can promote infections in three ways: (1) mediating further infection by transmitting pathogen-related molecules; (2) participating in the immune escape of pathogens; and (3) inhibiting immune responses by favoring immune cell apoptosis. Second, exosomes play anti-infection roles through: (1) inhibiting pathogen proliferation and infection directly; (2) inducing immune responses such as those related to the function of monocyte-macrophages, NK cells, T cells, and B cells. We believe that exosomes act as "bridges" during pathogen infections through the mechanisms mentioned above. The purpose of this review is to describe present findings regarding exosomes and pathogen infections, and highlight their enormous potential in clinical diagnosis and treatment. We discuss two opposit...Continue Reading

References

Jun 15, 1983·Biochemical and Biophysical Research Communications·C Harding, P Stahl
Aug 3, 2002·Nature Reviews. Immunology·Clotilde ThérySebastian Amigorena
May 14, 2003·Proceedings of the National Academy of Sciences of the United States of America·Inkyu HwangJonathan Sprent
Jul 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elodie SeguraClotilde Théry
Nov 26, 2008·Microbes and Infection·Ana Claudia Trocoli TorrecilhasMaria Júlia Manso Alves
Dec 23, 2008·FEBS Letters·Matthias HusmannSucharit Bhakdi
Apr 16, 2009·Journal of Proteome Research·Javier Conde-VancellsJuan M Falcon-Perez
Nov 18, 2010·Malaria Journal·Fernanda M F CamposLuzia H Carvalho
Dec 22, 2010·Seminars in Immunopathology·Nathalie Chaput, Clotilde Théry
Apr 21, 2011·Nature Communications·María MittelbrunnFrancisco Sánchez-Madrid
Nov 3, 2011·PloS One·Lorena Martin-JaularHernando A Del Portillo
Jun 23, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Prachi P SinghJeffery S Schorey
Feb 14, 2013·Proteomics·Jos F BrouwersWillem Stoorvogel
Jun 19, 2013·Biological Chemistry·Fatemeh Momen-HeraviWinston Patrick Kuo
Jun 28, 2013·Frontiers in Genetics·Alessandro LaganàAlfredo Ferro
Jul 9, 2013·Nature Immunology·Jianhua LiZhenghong Yuan
Dec 26, 2013·Stem Cells and Development·Bin ZhangSai Kiang Lim
Jan 28, 2014·Journal of Ovarian Research·Allison BeachSham S Kakar
Feb 12, 2014·Journal of Hepatology·François-Loïc Cosset, Marlène Dreux
Apr 5, 2014·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Yue WangZiqiang Cheng
Apr 25, 2014·Cellular Immunology·Andrea Sobo-VujanovicNikola L Vujanovic
May 24, 2014·Cold Spring Harbor Perspectives in Biology·Judith Klumperman, Graça Raposo
Jun 19, 2014·The Journal of Biological Chemistry·Elizabeth JaworskiFatah Kashanchi
Aug 20, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Mu LiAlexander V Vlassov
Dec 10, 2014·EMBO Reports·Jeffrey S SchoreyVictoria L Smith
Jan 21, 2015·Frontiers in Immunology·Masafumi Nakayama
Mar 1, 2015·Genomics, Proteomics & Bioinformatics·Jian ZhangShuangli Mi
Mar 21, 2015·PLoS Neglected Tropical Diseases·Satish P RamachandraRaoPierluigi Mauri
Apr 29, 2015·Proceedings of the National Academy of Sciences of the United States of America·Toshihide TakeuchiYoshitaka Nagai

❮ Previous
Next ❯

Citations

Feb 1, 2019·The Journal of General Virology·Jennifer L WelchChioma M Okeoma
Mar 5, 2019·Plant Signaling & Behavior·Saul Jimenez-JimenezLuis Cárdenas
Mar 23, 2019·Annals of the New York Academy of Sciences·James A Shapiro
Aug 9, 2019·Future Medicinal Chemistry·Bhawana SinghAbhay R Satoskar
Oct 17, 2019·Pharmaceutics·Veena VijayanIn-Kyu Park
Sep 28, 2018·Frontiers in Microbiology·Marije E KuipersEsther N M Nolte-'t Hoen
Feb 9, 2019·Cellular and Molecular Life Sciences : CMLS·Houman KahrobaNasser Samadi
Jul 9, 2020·Scientific Reports·Elena Martínez-GonzálezAmanda Fernández-Rodríguez
Sep 10, 2020·International Journal of General Medicine·Shosaku NomuraTomoki Ito
Jul 2, 2020·International Journal of Nanomedicine·Yan WangQi Li
Jul 18, 2020·Molecular Biology Reports·Behzad Cheshmi, Hamid Cheshomi
Jan 31, 2019·Frontiers in Immunology·Zhenyu WuXi Sun
Nov 13, 2019·Emerging Microbes & Infections·Ritu MishraAkhil C Banerjea
Feb 23, 2020·Frontiers in Immunology·Kehinde Adebayo BabatundePierre-Yves Mantel
Aug 6, 2020·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Davod JafariAli Samadikuchaksaraei
Sep 3, 2019·Frontiers in Immunology·Jianjun WangRodolfo C Garcia
Nov 6, 2020·PLoS Computational Biology·Carolin ZitzmannAlan S Perelson
Nov 17, 2020·Frontiers in Cellular and Infection Microbiology·Mohsin NawazJinlin Zhou
Jan 28, 2021·Cell Reports·Matthew R HendricksJennifer M Bomberger
Jan 8, 2021·Journal of Clinical Medicine·Fantahun BiadglegneUlrich Sack
Feb 23, 2021·Frontiers in Oncology·Ying TangDa-Yong Zheng
Jul 10, 2019·Trends in Parasitology·Vignesh RathinasamyBrian M Cooke
Jun 4, 2020·Chemical Research in Toxicology·Linlin Zhao, Philip Sumberaz
Apr 30, 2021·Cell Biology International·Ghadi N AlzhraniNehal Elsherbiny
Jun 19, 2021·Frontiers in Cellular and Infection Microbiology·Ranya ElsayedChristopher W Cutler
Jun 7, 2019·Pathology, Research and Practice·Li-Man LiQing-Yuan Cheng
Oct 31, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jianjun WangXin Tang

❮ Previous
Next ❯

Methods Mentioned

BETA
transmission electron microscopy
bronchoalveolar lavages

Software Mentioned

PALM
STORM

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

B cells: Gene Expression

B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.

Related Papers

Current Neuropharmacology
Allison L Isola, Suzie Chen
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Biyu Xu, Ting Wang
Archivum Immunologiae Et Therapiae Experimentalis
Liliana Czernek, Markus Düchler
© 2022 Meta ULC. All rights reserved